Results 111 to 120 of about 5,732,477 (296)
Frontiers in Veterinary ScienceThe city of Houston, Texas has a growing deficit of available and affordable rental units for low-income residents. Due to pet policies, the shortage of affordable housing potentially puts renters who own pets at greater risk of housing insecurity.
Tess M. Mascitelli +7 more
doaj +1 more source
The connected cutset connectivity of a graph
Discrete Mathematics, 1988 The connected (edge-)cutset connectivity \(c\kappa\) (G) \((c\kappa_ 1(G))\) of a graph G is the minimum cardinality of a vertex (edge) cutset S of G such that the subgraph induced by S is connected. Let \(\kappa\) (G) be the vertex-connectivity of G, \(\kappa_ 1(G)\) the edge-connectivity and \(\delta\) (G) the minimal degree.
openaire +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Scientific ReportsThis paper proposes a dynamic multi-scenario modeling approach for air conditioning (AC) cluster loads, integrating occupant behavior, spatiotemporal activity distributions, and meteorological factors.
ZhiYong Zhang, HaiYun Wang
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Connections, connections, connections [PDF]
Nature Reviews Molecular Cell Biology, 2017 openaire +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
The connective tissue connection [PDF]
Nature Structural & Molecular Biology, 1994 openaire +2 more sources