Results 41 to 50 of about 127,219 (252)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
CONNECTION BETWEEN PERFORMANCE TESTING METHODS IN HUNGARIAN PIG BREEDING BASED ON GENETIC CORRELATION COEFFICIENTS [PDF]
Poljoprivreda, 2000 Genetic analysis was conducted on Hungarian pig seed stocks. The breeds, which were used in the investigation, were Hungarian Large White, Hungarian Landrace, Duroc, and Pietrain respectively.
Istvan Nagy +3 more
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Advances in Difference Equations, 2021 The principal aim of the current article is to establish new formulas of Chebyshev polynomials of the sixth-kind. Two different approaches are followed to derive new connection formulas between these polynomials and some other orthogonal polynomials. The
Waleed M. Abd-Elhameed +1 more
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The relationship between molecular connectivity and partition coefficients
Journal of Pharmacy and Pharmacology, 1982 Abstract Kier & Hall (1976) demonstrated that a relationship existed between molecular connectivity and Log P (the Log of the octanol/water partition coefficient) for several classes of compounds and also for the combined classes. This work utilized a number of Log P values calculated using π values.
J C, Boyd +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Spatial time-series modeling with R system
Lietuvos Matematikos Rinkinys, 2004 In this paper we propose modeling technique, which was applied to multivariate time series data that correspond to different spatial locations (spatial time series). ARIMA model class is considered for each location.
Laura Šaltytė, Kęstutis Dučinskas
doaj +3 more sources
A New Wavelet Method for Solving a Class of Nonlinear Volterra-Fredholm Integral Equations
Abstract and Applied Analysis, 2014 A new approach, Coiflet-type wavelet Galerkin method, is proposed for numerically solving the Volterra-Fredholm integral equations. Based on the Coiflet-type wavelet approximation scheme, arbitrary nonlinear term of the unknown function in an equation ...
Xiaomin Wang
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source