Results 71 to 80 of about 131,872 (281)

The relationship between molecular connectivity and partition coefficients

Journal of Pharmacy and Pharmacology, 1982
Abstract Kier & Hall (1976) demonstrated that a relationship existed between molecular connectivity and Log P (the Log of the octanol/water partition coefficient) for several classes of compounds and also for the combined classes. This work utilized a number of Log P values calculated using π values.
J C, Boyd, J S, Millership, A D, Woolfson   +2 more
openaire   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Spatial time-series modeling with R system

Lietuvos Matematikos Rinkinys, 2004
In this paper we propose modeling technique, which was applied to multivariate time series data that correspond to different spatial locations (spatial time series). ARIMA model class is considered for each location.
Laura Šaltytė, Kęstutis Dučinskas
doaj   +3 more sources

A New Wavelet Method for Solving a Class of Nonlinear Volterra-Fredholm Integral Equations

Abstract and Applied Analysis, 2014
A new approach, Coiflet-type wavelet Galerkin method, is proposed for numerically solving the Volterra-Fredholm integral equations. Based on the Coiflet-type wavelet approximation scheme, arbitrary nonlinear term of the unknown function in an equation ...
Xiaomin Wang
doaj   +1 more source

9j-coefficients and higher [PDF]

, 2020
The su(2) 3j-coefficients (or 3j-symbols), 6j-coefficients, 9j-coefficients and higher (referred to as 3nj-coefficients) play a crucial role in various physical applications dealing with the quantization of angular momentum.
J. Van der Jeugt, Van der Jeugt, Joris
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Standardized Coefficients of Multiple Regression Beyond One and Multicollinearity Diagnostics

Axioms
Standardized coefficients of multiple regression, also known as beta coefficients, by absolute value are usually smaller than one, but sometimes they can exceed one.
Stan Lipovetsky
doaj   +1 more source

On Subspaces of an Almost 𝝋-Lagrange Space

International Journal of Mathematics and Mathematical Sciences, 2012
We discuss the subspaces of an almost 𝜑-Lagrange space (APL space in short). We obtain the induced nonlinear connection, coefficients of coupling, coefficients of induced tangent and induced normal connections, the Gauss-Weingarten formulae, and the ...
P. N. Pandey, Suresh K. Shukla
doaj   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source