Results 101 to 110 of about 292,639 (308)
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Дифференциальная геометрия многообразий фигур, 2018 The congruence of hypercentred planes is investigated in n-dimensional projective space. The congruence is a holonomic smooth manifold. It is proved that curvature object for the fundamental-group connection in the principal fibre bundle associated ...
A. Vyalova
doaj
Principal bundles under reductive groups [PDF]
arXiv, 2015 Let $k$ be a field of characteristic $0$. We consider principal bundles over a $k$-scheme with reductive structure group (not necessarily of finite type). It is showm in particular that for $k$ algebraically closed there exists on any complete connected $k$-scheme a universal such bundle.
arxiv
Interplay of integrins and selectins in metastasis
Molecular Oncology, EarlyView.Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva +2 more
wiley +1 more source
Parallel Connections Over Symmetric Spaces [PDF]
arXiv, 1997 Let M be a simply connected Riemannian symmetric space, with at most one flat direction. We show that every Riemannian (or unitary) vector bundle with parallel curvature over M is an associated vector bundle of a canonical principal bundle, with the connection inherited from the principal bundle.
arxiv
Connections and Frame Bundle Reductions [PDF]
arXiv, 2020 In general relativity, the gravitational potential is represented by the Levi-Civita connection, the only symmetric connection preserving the metric. On a differentiable manifold, a metric identifies with an orthogonal structure, defined as a Lorentz reduction of the frame bundle.
arxiv
Criterion for existence of a logarithmic connection on a principal bundle over a smooth complex projective variety [PDF]
, 2020 Sudarshan Gurjar, Arjun Paul
openalex +1 more source
The Orbit Bundle Picture of Cotangent Bundle Reduction [PDF]
, 2000 Cotangent bundle reduction theory is a basic and well developed subject in which one performs symplectic reduction on cotangent bundles. One starts with a (free and proper) action of a Lie group G on a configuration manifold Q, considers its natural ...
Marsden, Jerrold E., Perlmutter, Matthew
core +1 more source
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source