Results 51 to 60 of about 5,540 (286)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
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T-duality as correspondences of categorified principal bundles with adjusted connections [PDF]
, 2023 Christian Saemann, Hyungrok Kim
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Hierarchy of spaces of projective connection
Дифференциальная геометрия многообразий фигур, 2018 We consider the bundle of projective frames over a smooth manifold, i. e. the principal bundle whose typical fiber is the projective group. The giving fundamental-group connection in this bundle transforms it into a space of general projective connection.
Yu. Shevchenko
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
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Connections on principal bundles over curves in positive characteristics [PDF]
Pacific Journal of Mathematics, 2003 Let \(X\) be an irreducible smooth projective curve over an algebraically closed field \(k\) of characteristic \(p>5\). Let \(E_G\) be a principal \(G\)-bundle over \(X\), where \(G\) is a connected reductive algebraic group over \(k\). The aim of the present paper is to provide a criterion for the existence of a connection on the bundle \(E_G\).
Biswas, Indranil, Subramanian, S.
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FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
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Дифференциальная геометрия многообразий фигур, 2019 This research is realized by Cartan — Laptev method (with prolongations and scopes, moving frame and exterior forms). In this paper we consider a space П of centered m-planes (a space of all centered planes of the dimension m). This space is considered
Е. Belova, O. Belova
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Defining the mobility range of a hinge-type connection using molecular dynamics and metadynamics.
PLoS ONE, 2020 A designed disulfide-rich β-hairpin peptide that dimerizes spontaneously served as a hinge-type connection between proteins. Here, we analyze the range of dynamics of this hinge dimer with the aim of proposing new applications for the DNA-encodable ...
Philip Horx, Armin Geyer
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On Invariant Connections over a Principal Fibre Bundle [PDF]
Nagoya Mathematical Journal, 1958 The invariant affine connection over a coset space G/J of a Lie group G have been discussed by various authors. Recently, Nomizu [8] gave a systematic study of this problem when J is reductible in G. Among other results, he established a 1-1 correspondence between the invariant affine connections and certain multilinear mappings, and calculated the ...
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