Results 61 to 70 of about 3,456,047 (292)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Hierarchy of spaces of projective connection
Дифференциальная геометрия многообразий фигур, 2018 We consider the bundle of projective frames over a smooth manifold, i. e. the principal bundle whose typical fiber is the projective group. The giving fundamental-group connection in this bundle transforms it into a space of general projective connection.
Yu. Shevchenko
doaj
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Functoriality of Principal Bundles and Connections
, 2019 Perhaps the most important contribution of gauge theory to general mathematics is to point out the importance of association functors. Emphasizing category theory we characterize association functors by two of their natural properties and use this characterization to establish an equivalence between the category of principal bundles and a suitably ...
Moncada, Gustavo Amilcar Saldaña +1 more
openaire +2 more sources
, 2010 International audienceWe show that the holonomy of a connection defined on a principal composite bundle is related by a non-Abelian Stokes theorem to the composition of the holonomies associated with the connections of the component bundles of the ...
David Viennot, Viennot, D.
core +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Factorial Analysis Quantifies the Effects of Pediatric Discharge Bundle on Hospital Readmission.
, 2021 BACKGROUND AND OBJECTIVES: Factorial design of a natural experiment was used to quantify the benefit of individual and combined bundle elements from a 4-element discharge transition bundle (checklist, teach-back, handoff to outpatient providers, and ...
Cooperberg, David +7 more
core +1 more source
Research Object Bundle 1.0 [PDF]
, 2014 This specification defines a file format for storage and distribution of Research Objects as a ZIP archive; called a Research Object Bundle (RO Bundle).
Haines, Robert +4 more
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source