Results 51 to 60 of about 105,811 (271)
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Equivariant holonomy of U(1)-bundles
, 2019 We define the equivariant holonomy of an invariant connection on a principal U(1)-bundle. The properties of the ordinary holonomy are generalized to the equivariant setting.
Perez, Roberto Ferreiro
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Relative connections on principal bundles and relative equivariant structures
Differential Geometry and its Applications, 2023 We investigate relative holomorphic connections on a principal bundle over a family of compact complex manifolds. A sufficient condition is given for the existence of a relative holomorphic connection on a holomorphic principal bundle over a complex analytic family. We also introduce the notion of relative equivariant bundles and establish its relation
Poddar, Mainak, Singh, Anoop
openaire +3 more sources
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Pseudo-Sasakian manifolds endowed with a contact conformal connection
International Journal of Mathematics and Mathematical Sciences, 1986 Pseudo-Sasakian manifolds M˜(U,ξ,η˜,g˜) endowed with a contact conformal connection are defined.
Vladislav V. Goldberg, Radu Rosca
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Coupled equations for Kähler metrics and Yang-Mills connections
, 2013 We study equations on a principal bundle over a compact complex manifold coupling a connection on the bundle with a Kahler structure on the base. These equations generalize the conditions of constant scalar curvature for a Kahler metric and Hermite-Yang ...
Garcia-Fernandez, M. +2 more
core +2 more sources
A geometric approach to discrete connections on principal bundles
Journal of Geometric Mechanics, 2013 This work revisits, from a geometric perspective, the notion of discrete connection on a principal bundle, introduced by M. Leok, J. Marsden and A. Weinstein. It provides precise definitions of discrete connection, discrete connection form and discrete horizontal lift and studies some of their basic properties and relationships. An existence result for
Fernández, J., Zuccalli, Marcela
openaire +3 more sources