Results 51 to 60 of about 5,522 (253)
Functoriality of Principal Bundles and Connections
, 2019 Perhaps the most important contribution of gauge theory to general mathematics is to point out the importance of association functors. Emphasizing category theory we characterize association functors by two of their natural properties and use this characterization to establish an equivalence between the category of principal bundles and a suitably ...
Moncada, Gustavo Amilcar Saldaña +1 more
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On Invariant Connections over a Principal Fibre Bundle [PDF]
Nagoya Mathematical Journal, 1958 The invariant affine connection over a coset space G/J of a Lie group G have been discussed by various authors. Recently, Nomizu [8] gave a systematic study of this problem when J is reductible in G. Among other results, he established a 1-1 correspondence between the invariant affine connections and certain multilinear mappings, and calculated the ...
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Дифференциальная геометрия многообразий фигур, 2019 This research is realized by Cartan — Laptev method (with prolongations and scopes, moving frame and exterior forms). In this paper we consider a space П of centered m-planes (a space of all centered planes of the dimension m). This space is considered
Е. Belova, O. Belova
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Defining the mobility range of a hinge-type connection using molecular dynamics and metadynamics.
PLoS ONE, 2020 A designed disulfide-rich β-hairpin peptide that dimerizes spontaneously served as a hinge-type connection between proteins. Here, we analyze the range of dynamics of this hinge dimer with the aim of proposing new applications for the DNA-encodable ...
Philip Horx, Armin Geyer
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
General Relativity with a Positive Cosmological Constant Λ as a Gauge Theory
Axioms, 2019 In this paper, we show that the general relativity action (and Lagrangian) in recent Einstein⁻Palatini formulation is equivalent in four dimensions to the action (and Langrangian) of a gauge field.
Marta Dudek, Janusz Garecki
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source