Results 51 to 60 of about 3,456,047 (292)
Principal bundles, groupoids, and connections [PDF]
Banach Center Publications, 2007 We clarify in which precise sense the theory of principal bundles and the theory of groupoids are equivalent; and how this equivalence of theories, in the differentiable case, reflects itself in the theory of connections. The method used is that of synthetic differential geometry. Introduction. In this note, we make explicit a sense in which the theory
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Horizontal lifts of projectable linear connection to semi-tangent bundle
, 2021 The main aim of this article is to study the horizontal lifts of projectable linear connectionin the semi-tangent bundle tM. The properties of complete and horizontal lifts of projectable linear connection for semi-tangent bundle tM are also investigated.
Yildirim, Furkan +2 more
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
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Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Pseudo-Sasakian manifolds endowed with a contact conformal connection
International Journal of Mathematics and Mathematical Sciences, 1986 Pseudo-Sasakian manifolds M˜(U,ξ,η˜,g˜) endowed with a contact conformal connection are defined.
Vladislav V. Goldberg, Radu Rosca
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Relative connections on principal bundles and relative equivariant structures
Differential Geometry and its Applications, 2023 We investigate relative holomorphic connections on a principal bundle over a family of compact complex manifolds. A sufficient condition is given for the existence of a relative holomorphic connection on a holomorphic principal bundle over a complex analytic family. We also introduce the notion of relative equivariant bundles and establish its relation
Poddar, Mainak, Singh, Anoop
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
On Invariant Connections over a Principal Fibre Bundle [PDF]
Nagoya Mathematical Journal, 1958 The invariant affine connection over a coset space G/J of a Lie group G have been discussed by various authors. Recently, Nomizu [8] gave a systematic study of this problem when J is reductible in G. Among other results, he established a 1-1 correspondence between the invariant affine connections and certain multilinear mappings, and calculated the ...
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