Results 61 to 70 of about 459,615 (259)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Using nature-based citizen science initiatives to enhance nature connection and mental health

Frontiers in Environmental Science
The global rise in mental health issues underscores the critical importance of assessing the mental health benefits of engaging with nature. Beyond their primary aim of involving citizens in scientific data collection, nature-based citizen science ...
Rachel R. Y. Oh, Rachel R. Y. Oh, Andres F. Suarez-Castro, Richard A. Fuller, Michael Tervo, Kevin Rozario, Kevin Rozario, Kevin Rozario, Kevin Rozario, Birte Peters, Birte Peters, Shawan Chowdhury, Shawan Chowdhury, Shawan Chowdhury, Shawan Chowdhury, Julia von Gönner, Julia von Gönner, Julia von Gönner, Martin Friedrichs-Manthey, Martin Friedrichs-Manthey, Martin Friedrichs-Manthey, Ambros Berger, Tracy Schultz, Angela J. Dean, Angela J. Dean, Ayesha Tulloch, Aletta Bonn, Aletta Bonn, Aletta Bonn   +28 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

How Education Can Be Leveraged to Foster Adolescents’ Nature Connection

, 2023
Scientific research on the relationship between nature and health/wellbeing has increased dramatically in recent years. Contact with nature during childhood, both within formal and informal learning contexts, has diverse demonstrated positive effects on young people.
Heyman, Sofie, Jansen, Toon, Sass, Wanda, Michels, Nele, Boeve-de Pauw, Jelle, van Petegem, Peter, Keune, Hans   +6 more
openaire   +4 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Connecting to Self and to Nature

Abstract The practice of Connecting to self and to nature is based on checking in with ourselves and cultivating connection through our senses and from there creating new insights and pathways toward sustainable, regenerative transformations. It aligns with principles of mindfulness, interbeing, and ecological consciousness and allows
Ruth Förster, Anaïs Sägesser
openaire   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Perceived Connectedness to Nature in Fitness Enthusiasts, Golfers, and Climbers: A Cross‐Sectional Comparative Study

Health Science Reports
Background and Aims Connectedness to nature (CN) refers to the degree to which individuals feel a connection with the natural environment. CN has been associated with physical activity, life satisfaction, well‐being, and pro‐environmental behavior ...
Daniela Haluza, Markus Spletzer, Julia Ortmann, David Jungwirth   +3 more
doaj   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source