Results 61 to 70 of about 1,438,169 (315)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Feasibility of a Personal Neuromorphic Emulation

Entropy
The representation of intelligence is achieved by patterns of connections among neurons in brains and machines. Brains grow continuously, such that their patterns of connections develop through activity-dependent specification, with the continuing ...
Don M. Tucker, Phan Luu
doaj   +1 more source

Metric-affine f(R) theories of gravity

, 2006
General Relativity assumes that spacetime is fully described by the metric alone. An alternative is the so called Palatini formalism where the metric and the connections are taken as independent quantities.
Allemandi, Allemandi, Barrow, Barrow, Benn, Birrell, Buchbinder, Buchdahl, Capozziello, Carroll, Carroll, Carroll, Cembranos, Chiba, Dick, Dolgov, Domínguez, Dvali, Faraoni, Ferraris, Flanagan, Flanagan, Gasperini, Hall, Hehl, Hehl, Hehl, Hehl, Hehl, Kunstatter, Maartens, Majumbar, Meng, Meng, Meng, Misner, Nojiri, Novikov, Padmanabhan, Papapetrou, Randall, Rubilar, Sandberg, Schakel, Schrödinger, Sotiriou, Sotiriou, Starobinsky, Stefano Liberati, Stone, Tapia, Thomas P. Sotiriou, Tsamparlis, Utiyama, Vassilevich, Vilkovisky, Vollick, Vollick, Vollick, Wald, Will, Will   +61 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The cognitive principles of learning underlying the 5E Model of Instruction

International Journal of STEM Education, 2022
Over 34 years since its conception, research in educational settings has found evidence for the effectiveness of the 5E Instructional Model. Indeed, several studies have reported evidence of a better conceptual understanding of scientific ideas and ...
Héctor Ruiz-Martín, Rodger W. Bybee
doaj   +1 more source

Some aspects of noncommutative differential geometry [PDF]

, 1995
We discuss in some generality aspects of noncommutative differential geometry associated with reality conditions and with differential calculi. We then describe the differential calculus based on derivations as generalization of vector fields, and we ...
Dubois-Violette, Michel
core  

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Monad Transformers for Backtracking Search [PDF]

Electronic Proceedings in Theoretical Computer Science, 2014
This paper extends Escardo and Oliva's selection monad to the selection monad transformer, a general monadic framework for expressing backtracking search algorithms in Haskell.
Jules Hedges
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Common neighbours and the local-community-paradigm for topological link prediction in bipartite networks

New Journal of Physics, 2015
Bipartite networks are powerful descriptions of complex systems characterized by two different classes of nodes and connections allowed only across but not within the two classes.
Simone Daminelli, Josephine Maria Thomas, Claudio Durán, Carlo Vittorio Cannistraci   +3 more
doaj   +1 more source