Results 41 to 50 of about 116,056 (259)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Monad Transformers for Backtracking Search [PDF]

Electronic Proceedings in Theoretical Computer Science, 2014
This paper extends Escardo and Oliva's selection monad to the selection monad transformer, a general monadic framework for expressing backtracking search algorithms in Haskell.
Jules Hedges
doaj   +1 more source

Prolongations of tensor fields and connections to tangent bundles I -- General theory -- [PDF]

Journal of the Mathematical Society of Japan, 1966
Publisher Summary Using the notion of complete lift it is shown that G structures as a pseudo-Riemannian structure, an almost complex structure and a symplectic structure on M induce similar structures on the tangent bundle T(M). An unexpected but perhaps more interesting result is that each pseudo-Riemannian (resp.
YANO, Kentaro, KOBAYASHI, Shoshichi
openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Feasibility of a Personal Neuromorphic Emulation

Entropy
The representation of intelligence is achieved by patterns of connections among neurons in brains and machines. Brains grow continuously, such that their patterns of connections develop through activity-dependent specification, with the continuing ...
Don M. Tucker, Phan Luu
doaj   +1 more source

The cognitive principles of learning underlying the 5E Model of Instruction

International Journal of STEM Education, 2022
Over 34 years since its conception, research in educational settings has found evidence for the effectiveness of the 5E Instructional Model. Indeed, several studies have reported evidence of a better conceptual understanding of scientific ideas and ...
Héctor Ruiz-Martín, Rodger W. Bybee
doaj   +1 more source

Connections between the Sznajd model with general confidence rules and graph theory [PDF]

Physical Review E, 2012
The Sznajd model is a sociophysics model, that is used to model opinion propagation and consensus formation in societies. Its main feature is that its rules favour bigger groups of agreeing people. In a previous work, we generalized the bounded confidence rule in order to model biases and prejudices in discrete opinion models.
Timpanaro, André M., Prado, Carmen P. C.   +1 more
openaire   +3 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Common neighbours and the local-community-paradigm for topological link prediction in bipartite networks

New Journal of Physics, 2015
Bipartite networks are powerful descriptions of complex systems characterized by two different classes of nodes and connections allowed only across but not within the two classes.
Simone Daminelli, Josephine Maria Thomas, Claudio Durán, Carlo Vittorio Cannistraci   +3 more
doaj   +1 more source