Results 61 to 70 of about 122,446 (305)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Monad Transformers for Backtracking Search [PDF]
Electronic Proceedings in Theoretical Computer Science, 2014 This paper extends Escardo and Oliva's selection monad to the selection monad transformer, a general monadic framework for expressing backtracking search algorithms in Haskell.
Jules Hedges
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
The cognitive principles of learning underlying the 5E Model of Instruction
International Journal of STEM Education, 2022 Over 34 years since its conception, research in educational settings has found evidence for the effectiveness of the 5E Instructional Model. Indeed, several studies have reported evidence of a better conceptual understanding of scientific ideas and ...
Héctor Ruiz-Martín, Rodger W. Bybee
doaj +1 more source
Lorentz Connections and Gravitation
, 2012 The different roles played by Lorentz connections in general relativity and in teleparallel gravity are reviewed. Some of the consequences of this difference are discussed.UNESP Univ Estadual Paulista, Inst Fis Teor, BR-01156970 São Paulo, BrazilUNESP ...
J. G. Pereira, Pereira, J. G.
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Advanced Concepts in Particle and Field Theory [PDF]
, 2016 Uniting the usually distinct areas of particle physics and quantum field theory, gravity and general relativity, this expansive and comprehensive textbook of fundamental and theoretical physics describes the quest to consolidate the elementary particles ...
Hübsch, Tristan
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Feasibility of a Personal Neuromorphic Emulation
EntropyThe representation of intelligence is achieved by patterns of connections among neurons in brains and machines. Brains grow continuously, such that their patterns of connections develop through activity-dependent specification, with the continuing ...
Don M. Tucker, Phan Luu
doaj +1 more source
Tracking intracellular dynamics through extracellular measurements. [PDF]
PLoS ONE, 2018 Extracellular recordings of neuronal cells are frequently a part of in vitro and in vivo experimental studies as a means of monitoring network-level dynamics. Their connections to intracellular dynamics are not well understood. Single-unit recordings are
Franz Hamilton +2 more
doaj +1 more source