Results 51 to 60 of about 15,852,357 (241)

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Micropolar Modeling of Shear Wave Dispersion in Marine Sediments and Deep Earth Materials: Deriving Scaling Laws

Geosciences
We draw connections between eight different theories used to describe microscopic (atomic) and macroscopic (seismological) scales. In particular, we show that all these different theories belong to a particular case of a single partial differential ...
Rafael Abreu
doaj   +1 more source

Information and Physics

Information, 2012
In this paper I discuss the question: what comes first, physics or information? The two have had a long-standing, symbiotic relationship for almost a hundred years out of which we have learnt a great deal.
Vlatko Vedral
doaj   +1 more source

Bundle geometry of the connection space, covariant Hamiltonian formalism, the problem of boundaries in gauge theories, and the dressing field method

Journal of High Energy Physics, 2021
We take advantage of the principal bundle geometry of the space of connections to obtain general results on the presymplectic structure of two classes of (pure) gauge theories: invariant theories, and non-invariant theories satisfying two restricting ...
J. François
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Some functorial prolongations of general connections [PDF]

, 2018
summary:We consider the problem of prolongating general connections on arbitrary fibered manifolds with respect to a product preserving bundle functor.
Ivan Kolář, Kolář, Ivan
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

General lattice theory

, 1978
Includes bibliographical references (pages, 316-361) and index.Print version record.Front Cover; General Lattice Theory; Copyright Page; Contents; Preface and Acknowledgements; Introduction; CHAPTER I. FIRST CONCEPTS; CHAPTER II.
Grätzer, George, Gratzer, George A.
core