Results 51 to 60 of about 116,056 (259)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Abstract and Applied Analysis, 2014 This paper is concerned with approximation on variable Lρp(·) spaces associated with a general exponent function p and a general bounded Borel measure ρ on an open subset Ω of Rd. We mainly consider approximation by Bernstein type linear operators. Under
Bing-Zheng Li, Ding-Xuan Zhou
doaj +1 more source
The image of society in the theory of Islamic literature
آداب الكوفة, 2011 One of the important principles in the theory of Islamic literature is to look at any social phenomenon through its true location in the context of the social system that is subject to the divine laws that govern the movement of history and ...
عبد الكريم المحمود
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A connection between gravitational scalar-tensor theories and generalized hybrid theories
Physics Letters BWe establish a correspondence between higher-derivative gravitational scalar-tensor theories of the form $Ψ(R,(\nabla R)^2,\Box R)$ and generalized hybrid metric-Palatini models $f(R,\mathcal{R})$. Restricting to the physically relevant case of linear dependence on $\Box R$, we make explicit that both frameworks can be reformulated in the Einstein ...
Jonathan Ramírez +1 more
openaire +2 more sources
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
GeosciencesWe draw connections between eight different theories used to describe microscopic (atomic) and macroscopic (seismological) scales. In particular, we show that all these different theories belong to a particular case of a single partial differential ...
Rafael Abreu
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Information, 2012 In this paper I discuss the question: what comes first, physics or information? The two have had a long-standing, symbiotic relationship for almost a hundred years out of which we have learnt a great deal.
Vlatko Vedral
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Journal of High Energy Physics, 2021 We take advantage of the principal bundle geometry of the space of connections to obtain general results on the presymplectic structure of two classes of (pure) gauge theories: invariant theories, and non-invariant theories satisfying two restricting ...
J. François
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FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source