Results 51 to 60 of about 118,773 (236)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Children\u27s Understanding of the Semantics of Negation [PDF]

, 2010
The central focus of this project is to discover children’s understanding of the semantics, or meaning, of negation. Children’s knowledge of negation develops, in part, by directing attention away from a word to something else (i.e., contrast classes ...
Hiltz, Amanda
core  

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Zur Negation im Gegenwartsdeutschen und im Modernen Hocharabisch

, 2020
The present study is a contrastive and empirical investigation of the negative markers nicht in contemporary German (CG) and laysa, lam, lan, lammā, lāta, lā and mā in Modern Standard Arabic (MSA).
Qaddioui, Ouafaa
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Conjunctive queries with negation over DL-Lite: a closer look [PDF]

, 2013
While conjunctive query (CQ) answering over DL-Lite has been studied extensively, there have been few attempts to analyse CQs with negated atoms. This paper deepens the study of the problem.
Kontchakov, R, Gutiérrez-Basulto, V., Roman Kontchakov, Yazmín Ibañez-García, Ibañez-García, Y, Kostylev, E., Víctor Gutiérrez-Basulto, Ibáñez-García, Y., Gutiérrez-Basulto, V, Kostylev, Egor, Kontchakov, Roman, Egor V. Kostylev, Kostylev, Egor V., Gutierrez Basulto, Victor, Ibanez-Garcia, Yazmin   +14 more
core   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Negation 'presupposition' and metarepresentation: a response to Noel Burton-Roberts [PDF]

, 1999
Metalinguistic negation (MN) is interesting for at least the following two reasons: (a) it is one instance of the much broader, very widespread and various phenomenon of metarepresentational use in linguistic communication, whose semantic and pragmatic ...
Carston, R
core  

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source