Results 61 to 70 of about 14,177 (220)
On Affine Logic and {\L}ukasiewicz Logic [PDF]
, 2014 The multi-valued logic of {\L}ukasiewicz is a substructural logic that has been widely studied and has many interesting properties. It is classical, in the sense that it admits the axiom schema of double negation, [DNE]. However, our understanding of {\L}
Arthan, Rob, Oliva, Paulo
core
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Causals, Concessives, and the Scope of Negation
Kalbotyra, 2003 While wide-scope negation of a causal relation between two propositions P and Q – as in the English sentence I didn’t move because the rent was raised – is truth-conditionally underdetermined as to whether the speaker did or did not move and the rent was
Thorstein Fretheim
doaj
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Questions and Answers about Oppositions [PDF]
, 2011 A general characterization of logical opposition is given in the present paper, where oppositions are defined by specific answers in an algebraic question-answer game. It is shown that opposition is essentially a semantic relation of truth values between
Schang, Fabien
core
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Expletive negation : from imperatives to connectives : a formal diachronic approach
, 2022 Expletive negation is a non-canonical negation marker whose distribution is limited, across languages, to a certain set of predicates: apprehensive attitude verbs (‘fear’) exceptive (‘unless’) and prospective connectives (‘before’), comparative clauses (‘more/ less than’).
openaire +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
On fuzzy reasoning schemes [PDF]
, 1999 In this work we provide a short survey of the most frequently used fuzzy reasoning schemes. The paper is organized as follows: in the first section we introduce the basic notations and definitions needed for fuzzy inference systems; in the second ...
Fullér, Róbert
core +2 more sources