Results 181 to 190 of about 542,433 (374)

Interstitial lung disease in Malta [PDF]

open access: yes, 2012
Aim: To establish the prevalence, management and response to treatment of interstitial lung disease (ILD) in Malta. Methodology: The personal files of 102 living and 26 deceased patients with ILD under the care of 4 respiratory physicians were reviewed ...
Fenech, Manwel   +2 more
core  

Organising pneumonia can be the inaugural manifestation in connective tissue diseases, including Sjögren's syndrome

open access: yesEuropean Respiratory Review, 2010
Connective tissue diseases are known to be one of the causes of organising pneumonia (OP). However, this association is rare and signs of OP usually occur in the context of an already diagnosed disease. We report three cases of OP preceding the articular
A. C. Henriet   +6 more
doaj  

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Autoantibodies in childhood connective tissue diseases and in normal children.

open access: green, 1975
K M Goel   +4 more
openalex   +1 more source

Relation between regional echo intensity and myocardial connective tissue in chronic left ventricular disease. [PDF]

open access: bronze, 1984
T R Shaw   +6 more
openalex   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

open access: yesMolecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

A network-driven framework for enhancing gene-disease association studies in coronary artery disease [PDF]

open access: yesarXiv
Over the last decade, genome-wide association studies (GWAS) have successfully identified numerous genetic variants associated with complex diseases. These associations have the potential to reveal the molecular mechanisms underlying complex diseases and lead to the identification of novel drug targets.
arxiv  

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

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