Results 91 to 100 of about 1,199,246 (381)

IL-1β Inhibits Human Osteoblast Migration

Molecular Medicine, 2013
Bone has a high capacity for self-renewal and repair. Prolonged local secretion of interleukin 1β (IL-1β), however, is known to be associated with severe bone loss and delayed fracture healing.
Nina-Emily Hengartner, Jörg Fiedler, Anita Ignatius, Rolf E. Brenner   +3 more
doaj   +1 more source

What is the association between sickness absence, mortality and morbidity? [PDF]

, 2005
This paper examines the area-level relationships in England and Wales between sickness absence (‘incapacity benefit’), mortality and morbidity. It uses a random sample of incapacity benefit claims, and population counts of mortality and Census morbidity ...
C. Bambra, P. Norman, Armstrong, Beatty, Blondal, Disney, Fieldhouse, Fieldhouse, Kivimaki, Marmot, McCormick, Vahtera   +11 more
core   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Serum YKL-40 levels and disease characteristics in patients with rheumatoid arthritis

Caspian Journal of Internal Medicine, 2019
Background: The present study aimed to evaluate serum YKL-40 levels in patients with rheumatoid arthritis (RA) compared to healthy subjects and to search whether there is an association between YKL-40 levels and disease characteristics in RA. Methods: In
Mohammad Reza Jafari-Nakhjavani, Amir Ghorbanihaghjo, Babak Bagherzadeh-Nobari, Aida Malek-Mahdavi, Nadereh Rashtchizadeh   +4 more
doaj  

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Distribution of HLA-DRB1 Alleles in Patients With Antiphospholipid Syndrome and Their Association With Antiphospholipid Antibodies Presence and Damage Indexes

Journal of Immunology Research
Antiphospholipid syndrome (APS) is frequently coexisting with systemic lupus erythematosus (SLE) and the knowledge on its genetic background is essential. The objective of this work was to assess distribution of human leukocyte antigen (HLA)-DRB1 alleles
Ewa Haladyj, Barbara Stypinska, Agata Matusiewicz, Marzena Olesinska, Agnieszka Paradowska-Gorycka   +4 more
doaj   +1 more source

Metabolic Pattern of Systemic Sclerosis: Association of Changes in Plasma Concentrations of Amino Acid-Related Compounds With Disease Presentation

Frontiers in Molecular Biosciences, 2020
ObjectiveAmino acids (AA) and their derivatives play an integral role in the synthesis of structural and regulatory elements in human organisms and therefore pathologies such as systemic sclerosis that may alter the blood pattern of these compounds. This
Zaneta Smolenska, Magdalena Zabielska-Kaczorowska, Magdalena Zabielska-Kaczorowska, Anna Wojteczek, Barbara Kutryb-Zajac, Zbigniew Zdrojewski   +5 more
doaj   +1 more source

Elevated expression of type VII collagen in the skin of patients with systemic sclerosis. Regulation by transforming growth factor-beta. [PDF]

, 1994
A hallmark of systemic sclerosis (SSc) is the development of tissue fibrosis. Excessive production of several connective tissue components normally present in the dermis, including type I, III, V, and VI collagens as well as fibronectin and proteoglycans,
Christiano, Angela M., Iozzo, Renato V., Jimenez, Sergio A., Rudnicka, Lidia, Uitto, Jouni, Varga, John   +5 more
core   +3 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

High Prevalence of Cold Intolerance in Rheumatoid Arthritis: A Case–Control Study

Clinical Case Reports
Cold intolerance is more common in rheumatoid arthritis patients than control. Cold intolerance tends to develop after rheumatoid arthritis onset and is associated with longer disease duration, with pain and swelling being dominant features.
Mohsen Soroush, Rojin Farzaneh, Elaheh Babapour, Amirreza Jabbaripour Sarmadian, Sami Rassouli, Golrokh Hassanzadeh Behrouz, Amirreza Naseri, Maryam Mahmoudi, Kamal Esalatmanesh, Aida Malek Mahdavi, Alireza Khabbazi   +10 more
doaj   +1 more source