Results 81 to 90 of about 1,337,423 (351)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The expression and methylation status of vitamin D receptor gene in Behcet's disease

Immunity, Inflammation and Disease, 2019
Introduction Vitamin D has important roles as a natural immune modulator via regulating the expression of genes which have been implicated in the pathophysiology of autoimmune diseases.
Sam Seydi Shirvani, Mohammad Nouri, Ebrahim Sakhinia, Zohreh Babaloo, Golamreza jadideslam, Alipour Shahriar, Jafar Farhadi, Alireza khabbazi   +7 more
doaj   +1 more source

Pathological and histopatnotogical studies of the swimbladder of eels Anguilla anguitla infected by Angutlticpta crassus (Nemafoda: Dracuncuioidea) [PDF]

, 1993
The swimbladder lesions produced by Anguillicola crassus (Nematoda) infection, causing mass mortality among eels in Lake Balaton (Hungary) were studied by histological methods.
Baska, Ferenc, Csaba, G., Glávits, Róbert, Molnár, Kálmán, Székely, Csaba   +4 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Health-related quality of life impairment is equal for antiphospholipid syndrome whether primary or associated with systemic lupus erythematosus

Rheumatology
Introduction Antiphospholipid syndrome (APS) manifests with thrombosis and pregnancy losses and may significantly impair the health-related quality of life (HRQoL).
Ewa Haladyj, Agata Matusiewicz, Tomasz Wysocki, Marzena Olesinska   +3 more
doaj   +1 more source

Effects of Ti6Al4V Surfaces Manufactured through Precision Centrifugal Casting and Modified by Calcium and Phosphorus Ion Implantation on Human Osteoblasts

Metals, 2020
(1) In order to enable a more widespread use of uncemented titanium-based endoprostheses to replace cobalt-containing cemented endoprostheses for joint replacement, it is essential to achieve optimal osseointegrative properties and develop economic ...
Fiedler Jörg, Katmer Amet Betül, Michels Heiner, Kappelt Gerhard, Brenner Rolf Erwin   +4 more
doaj   +1 more source

What is the association between sickness absence, mortality and morbidity? [PDF]

, 2005
This paper examines the area-level relationships in England and Wales between sickness absence (‘incapacity benefit’), mortality and morbidity. It uses a random sample of incapacity benefit claims, and population counts of mortality and Census morbidity ...
C. Bambra, P. Norman, Armstrong, Beatty, Blondal, Disney, Fieldhouse, Fieldhouse, Kivimaki, Marmot, McCormick, Vahtera   +11 more
core   +1 more source

Effect of Th17 and Treg Axis Disorder on Outcomes of Pulmonary Arterial Hypertension in Connective Tissue Diseases

Mediators of Inflammation, 2014
This prospective cohort study is to verify the hypothesis that the balance of Th17 and Treg cells frequencies in the peripheral circulation is disturbed in patients with varying degrees of connective tissue diseases-associated pulmonary arterial ...
Saren Gaowa, Wenyong Zhou, Lilei Yu, Xiao-Ling Zhou, K. Liao, Kang Yang, Zhibing Lu, Hong Jiang, Xiaofeng Chen   +8 more
semanticscholar   +1 more source