Results 61 to 70 of about 201,576 (315)

Understanding the Role of Epithelial Cells in the Pathogenesis of Systemic Sclerosis

Cells
Systemic sclerosis (SSc) is an autoimmune fibrotic disorder affecting the skin and internal organs, categorized as either limited cutaneous SSc, where distal areas of skin are involved, or diffuse cutaneous SSc, where more extensive proximal skin ...
Lydia Nagib, Anshul Sheel Kumar, Richard Stratton   +2 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Quantitative measures of tissue mechanics to detect hypermobile Ehlers-Danlos syndrome and hypermobility syndrome disorders: a systematic review

, 2020
© 2020, The Author(s). Hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSD) are heritable connective tissue disorders associated with pain, activity limitations and participation restrictions.
Palmer, Shea, Young, Georgina, Riglar, Matthew, Denner, Elise, Scannell, Holly, Webb, Sarah   +5 more
core   +1 more source

The expression and methylation status of vitamin D receptor gene in Behcet's disease

Immunity, Inflammation and Disease, 2019
Introduction Vitamin D has important roles as a natural immune modulator via regulating the expression of genes which have been implicated in the pathophysiology of autoimmune diseases.
Sam Seydi Shirvani, Mohammad Nouri, Ebrahim Sakhinia, Zohreh Babaloo, Golamreza jadideslam, Alipour Shahriar, Jafar Farhadi, Alireza khabbazi   +7 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Interstitial lung disease in the course of systemic connective tissue diseases: A common problem for rheumatologists and pulmonologists

, 2022
Interstitial lung disease is a common and dangerous complication of many rheumatic diseases. Progress over the last several years has increased diagnostic capabilities, led to emergence of new therapeutic options and, above all, resulted in deeper ...
Szymanowska-Narloch, Amelia; Department of Allergology, University Clinical Centre in Gdańsk, Poland, Zdrojewski, Zbigniew; Department of Internal Medicine, Connective Tissue Diseases & Geriatrics, Medical University of Gdańsk, Poland, Gogulska, Zuzanna; Department of Internal Medicine, Connective Tissue Diseases & Geriatrics, Medical University of Gdańsk, Poland, Smoleńska, Żaneta; Department of Internal Medicine, Connective Tissue Diseases & Geriatrics, Medical University of Gdańsk, Poland   +3 more
core   +1 more source

Health-related quality of life impairment is equal for antiphospholipid syndrome whether primary or associated with systemic lupus erythematosus

Rheumatology
Introduction Antiphospholipid syndrome (APS) manifests with thrombosis and pregnancy losses and may significantly impair the health-related quality of life (HRQoL).
Ewa Haladyj, Agata Matusiewicz, Tomasz Wysocki, Marzena Olesinska   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Effects of Ti6Al4V Surfaces Manufactured through Precision Centrifugal Casting and Modified by Calcium and Phosphorus Ion Implantation on Human Osteoblasts

Metals, 2020
(1) In order to enable a more widespread use of uncemented titanium-based endoprostheses to replace cobalt-containing cemented endoprostheses for joint replacement, it is essential to achieve optimal osseointegrative properties and develop economic ...
Fiedler Jörg, Katmer Amet Betül, Michels Heiner, Kappelt Gerhard, Brenner Rolf Erwin   +4 more
doaj   +1 more source