Results 41 to 50 of about 201,576 (315)

Increase of cell surface vimentin is associated with vimentin network disruption and subsequent stress-induced premature senescence in human chondrocytes

eLife, 2023
Accumulation of dysfunctional chondrocytes has detrimental consequences on the cartilage homeostasis and is thus thought to play a crucial role during the pathogenesis of osteoarthritis (OA).
Jana Riegger, Rolf E Brenner
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Original paper Assessment of the level of vaccine-induced anti-HBs antibodies in children with inflammatory systemic connective tissue diseases treated with immunosuppression

, 2015
Objectives : Protective vaccinations are the most effective method of prevention of type B virus hepatitis. The aim of the study was to determine whether in children receiving immunosuppressive therapy due to inflammatory systemic connective tissue ...
Małgorzata Kwiatkowska, Elżbieta Hernik, Agnieszka Gazda, Beata Kołodziejczyk, Izabela Szczygielska, Lidia Rutkowska-Sak   +5 more
core   +1 more source

Vitamin D and connective tissue diseases

, 2020
Objective and design: Recently, many studies have shown that the biologically active form of vitamin D—1,25(OH)2 D—is involved in many biological processes, including immune system modulation, and patients affected by various autoimmune diseases, such as
Cantatore F. P., Corrado A., Giardullo L., Berardi S.   +3 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Nontyphoidal Salmonella bacteremia in patients with connective tissue diseases

, 2012
[[abstract]]Background/Purpose: Nontyphoidal Salmonella (NTS) is a crucial pathogen in immunocompromised patients, especially those with connective tissue disease (CTD) and corticosteroid or immunosuppressant therapy. The aim of this study is to identify
Huang, CF;Chen, PL;Liu, MF;Lee, CC;Lee, NY;Chang, CM;Lee, HC;Wu, CJ;Ko, WC
core   +1 more source

Lipid Alterations in Systemic Sclerosis

Frontiers in Molecular Biosciences, 2021
Background: Systemic sclerosis (SSc) is an autoimmune disease with an elusive etiology and poor prognosis. Due to its diverse clinical presentation, a personalized approach is obligatory and needs to be based on a comprehensive biomarker panel. Therefore,
Zuzanna Gogulska, Zaneta Smolenska, Jacek Turyn, Adriana Mika, Zbigniew Zdrojewski   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Vascular changes in autoimmunological connective tissue diseases

, 2017
Vascular complications due to systemic connective tissue diseases pose a very difficult clinical problem. Due to the nature and location of the lesions, they very often prevent revascularization procedures and the conservative treatment is usually ...
Roszkiewicz, Marek; Klinika Dermatologii CSK MSWiA, Szymanska, Elzbieta; Dermatology Department, Central Clinical Hospital of the Ministry of the Interior and Administration in Warsaw, Poland, Lagun, Zuzanna; Klinika Dermatologii CSK MSWiA, Walecka, Irena; Klinika Dermatologii CSK MSWiA, Wieczorek, Marta; Klinika Dermatologii CSK MSWiA, Malewska, Aleksandra; Klinika Dermatologii CSK MSWiA   +5 more
core   +1 more source

Pulmonary hypertension in connective tissue diseases, new evidence and challenges [PDF]

, 2021
Contains fulltext : 232639.pdf (Publisher’s version ) (Open Access)Pulmonary arterial hypertension is a lethal complication of different connective tissue diseases such as systemic sclerosis, mixed connective tissue disease and systemic
Vonk, M.C., Vandecasteele, E., Dijk, A.P.J. van   +2 more
core   +1 more source