Results 61 to 70 of about 1,567,488 (349)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Connectome: Graph theory application in functional brain network architecture

Clinical Neurophysiology Practice, 2017
Network science and graph theory applications have recently spread widely to help in understanding how human cognitive functions are linked to neuronal network structure, thus providing a conceptual frame that can help in reducing the analytical brain ...
Fabrizio Vecchio, Francesca Miraglia, Paolo Maria Rossini   +2 more
doaj   +1 more source

Universal Negative Poisson Ratio of Self Avoiding Fixed Connectivity Membranes [PDF]

, 2001
We determine the Poisson ratio of self-avoiding fixed-connectivity membranes, modeled as impenetrable plaquettes, to be sigma=-0.37(6), in statistical agreement with the Poisson ratio of phantom fixed-connectivity membranes sigma=-0.32(4).
A. Cacciuto, A. E. H. Love, A. Travesset, B. Duplantier, B. Efron, C. F. Schmidt, D. J. Weidner, D. R. Nelson, E. Guitter, F. David, F. David, F. F. Abraham, F. F. Abraham, G. Thorleifsson, J. A. Aronovitz, J. H. Fendler, J. H. Fendler, J. Shao, K. E. Evans, K. J. Wiese, K. J. Wiese, L. D. Landau, M. Bowick, M. Bowick, M. Bowick, M. Falcioni, M. Goulian, M. J. Bowick, M. Kardar, M. Paczuski, M. S. Spector, N. Keskar, P. Le Doussal, P. Le Doussal, R. Lakes, T. Hwa, Y. Kantor, Y. Kantor, Z. Zhang   +38 more
core   +3 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Single-Cell RNA-Seq Reveals Developmental Origins and Ontogenetic Stability of Neurexin Alternative Splicing Profiles

Cell Reports, 2019
Summary: Neurexins are key synaptic organizers that are expressed in thousands of alternatively spliced isoforms. Because transsynaptic neurexin interactions with different postsynaptic molecules are largely isoform dependent, a cell type-level census of
David Lukacsovich, Jochen Winterer, Lin Que, Wenshu Luo, Tamas Lukacsovich, Csaba Földy   +5 more
doaj   +1 more source

Immunization of complex networks [PDF]

, 2002
Complex networks such as the sexual partnership web or the Internet often show a high degree of redundancy and heterogeneity in their connectivity properties. This peculiar connectivity provides an ideal environment for the spreading of infective agents.
Pastor-Satorras, Romualdo, Vespignani, Alessandro   +1 more
core   +2 more sources

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Accuracy Assessment of Digital Terrain Model Dataset Sources for Hydrogeomorphological Modelling in Small Mediterranean Catchments

Remote Sensing, 2018
Digital terrain models (DTMs) are a fundamental source of information in Earth sciences. DTM-based studies, however, can contain remarkable biases if limitations and inaccuracies in these models are disregarded.
Lukas Graf, Mariano Moreno-de-las-Heras, Maurici Ruiz, Aleix Calsamiglia, Julián García-Comendador, Josep Fortesa, José A. López-Tarazón, Joan Estrany   +7 more
doaj   +1 more source

Sex Commonalities and Differences in Obesity-Related Alterations in Intrinsic Brain Activity and Connectivity. [PDF]

, 2018
OBJECTIVE:This study aimed to characterize obesity-related sex differences in the intrinsic activity and connectivity of the brain's reward networks. METHODS:Eighty-six women (n = 43) and men (n = 43) completed a 10-minute resting functional magnetic ...
Anderberg, Baek, Balleine, Buzsaki, Chen, Clayton, Cornier, Coveleskie, Dong, Egorova, Garawi, Gartner, Geliebter, Goldstein, Gupta, Gupta, Haase, Haber, Hallam, Hogenkamp, Jokela, Kelley, Kelly, Krishnan, Lalitha, McIntosh, Murdaugh, Nakamura, Northoff, Park, Power, Price, Rapuano, Silveira, Smith, Sutin, Volkow, Volkow, Volkow, Wang, Ward, Zhang, Zhao, Zigmond, Zuo   +44 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source