Results 51 to 60 of about 467,517 (284)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A simple method to assess the fragmentation of freshwater fish meta-populations: Implications for river management and conservation

Ecological Indicators, 2021
Rivers are very vulnerable to fragmentation caused by the presence of man-made barriers. To restore river basin connectivity, numerous indices have been developed to calculate river fragmentation and optimise barrier mitigation actions.
Amaia A. Rodeles, David Galicia, Rafael Miranda   +2 more
doaj   +1 more source

Multiscale Topological Properties Of Functional Brain Networks During Motor Imagery After Stroke

, 2013
In recent years, network analyses have been used to evaluate brain reorganization following stroke. However, many studies have often focused on single topological scales, leading to an incomplete model of how focal brain lesions affect multiple network ...
Achard, Alstott, Babiloni, Bassett, Buch, Bullmore, Bullmore, Calautti, Compston, Costa, Crofts, Damoiseaux, De Vico Fallani, De Vico Fallani, Decety, Donatella Mattia, Doron, Downes, Fabio Babiloni, Fabrizio De Vico Fallani, Fallani, Febo Cincotti, Fischer, Floriana Pichiorri, Friston, Fugl Meyer, Gerloff, Gerloff, Gerloff, Ginestet, Giovanni Morone, Graziadio, Grefkes, Gross, Hantson, He, Honey, Ietswaart, Jang, Jeannerod, Johansen-Berg, Latora, Liu, Lotze, Luft, Marco Molinari, McFarland, Netz, Nolte, Nomura, Page, Pichiorri, Raichle, Rubinov, Schalk, Serrien, Shahid, Sharma, Shimizu, Sokal, Sporns, Stam, Strens, Supekar, Tombaugh, Tononi, Van Wijk, Varela, Volkmann, Vázquez, Wang, Ward, Westlake, Westlake, Wolf, Zalesky, Zar   +76 more
core   +3 more sources

Gutman index, edge-Wiener index and edge-connectivity

Transactions on Combinatorics, 2020
Summary: We study the Gutman index \(\mathrm{Gut}(G)\) and the edge-Wiener index \(W_e (G)\) of connected graphs \(G\) of given order \(n\) and edge-connectivity \(\lambda\). We show that the bound \(\mathrm{Gut}(G) \leq\frac{2^4 \cdot 3}{5^5 (\lambda+1)} n^5 + O(n^4)\) is asymptotically tight for \(\lambda \geq 8\). We improve this result considerably
Mazorodze, Jaya, Mukwembi, Simon, Vetrik, Tomas   +2 more
openaire   +2 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

General sum-connectivity index, general product-connectivity index, general Zagreb index and coindices of line graph of subdivision graphs

AKCE International Journal of Graphs and Combinatorics, 2017
The general sum-connectivity index, general product-connectivity index, general Zagreb index and coindices of line graphs of subdivision graphs of tadpole graphs, wheels and ladders have been reported in the literature.
Harishchandra S. Ramane, Vinayak V. Manjalapur, Ivan Gutman   +2 more
doaj   +1 more source

Atom–bond connectivity index of trees

Discrete Applied Mathematics, 2009
The recently introduced atom-bond connectivity (ABC) index has been applied up to now to study the stability of alkanes and the strain energy of cycloalkanes. Here, mathematical properties of the ABC index of trees are studied. Chemical trees with the extremal ABC values are found. In addition, it has been proven that among all trees, the star tree, Sn,
Furtula, Boris, Graovac, Ante, Vukičević, Damir   +2 more
openaire   +2 more sources

Atom-bond sum-connectivity index

Journal of Mathematical Chemistry, 2022
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Akbar Ali, Boris Furtula, Izudin Redžepović, Ivan Gutman   +3 more
openaire   +2 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

On Eccentricity-Based Topological Indices Study of a Class of Porphyrin-Cored Dendrimers

Biomolecules, 2018
It is revealed from the previous studies that there is a strong relation between the chemical characteristic of a chemical compound and its molecular structure.
Wei Gao, Zahid Iqbal, Muhammad Ishaq, Rabia Sarfraz, Muhammad Aamir, Adnan Aslam   +5 more
doaj   +1 more source