Results 61 to 70 of about 472,348 (280)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Multiscale Topological Properties Of Functional Brain Networks During Motor Imagery After Stroke

, 2013
In recent years, network analyses have been used to evaluate brain reorganization following stroke. However, many studies have often focused on single topological scales, leading to an incomplete model of how focal brain lesions affect multiple network ...
Achard, Alstott, Babiloni, Bassett, Buch, Bullmore, Bullmore, Calautti, Compston, Costa, Crofts, Damoiseaux, De Vico Fallani, De Vico Fallani, Decety, Donatella Mattia, Doron, Downes, Fabio Babiloni, Fabrizio De Vico Fallani, Fallani, Febo Cincotti, Fischer, Floriana Pichiorri, Friston, Fugl Meyer, Gerloff, Gerloff, Gerloff, Ginestet, Giovanni Morone, Graziadio, Grefkes, Gross, Hantson, He, Honey, Ietswaart, Jang, Jeannerod, Johansen-Berg, Latora, Liu, Lotze, Luft, Marco Molinari, McFarland, Netz, Nolte, Nomura, Page, Pichiorri, Raichle, Rubinov, Schalk, Serrien, Shahid, Sharma, Shimizu, Sokal, Sporns, Stam, Strens, Supekar, Tombaugh, Tononi, Van Wijk, Varela, Volkmann, Vázquez, Wang, Ward, Westlake, Westlake, Wolf, Zalesky, Zar   +76 more
core   +3 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The Eccentricity Version of Atom-Bond Connectivity Index of Linear Polycene Parallelogram Benzenoid ABC5(P(n,n))

Acta Chimica Slovenica, 2016
Among topological descriptors, connectivity indices are very important and they have a prominent role in chemistry. The atom-bond connectivity index of a connected graph G is defined as ABC(G)= where dv denotes the degree of vertex v of G and the ...
Wei Gao, Mohammad Reza Farahani, Muhammad Kamran Jamil   +2 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Remarks on Multiplicative Atom-Bond Connectivity Index

IEEE Access, 2019
The atom-bond connectivity (ABC) index is one of the most actively studied degree-based graph invariants that are found in a vast variety of chemical applications.
Riste Skrekovski, Darko Dimitrov, Jiemei Zhong, Hualong Wu, Wei Gao   +4 more
doaj   +1 more source

On the Computation of Some Topological Descriptors to Find Closed Formulas for Certain Chemical Graphs

Journal of Chemistry, 2021
In this research paper, we will compute the topological indices (degree based) such as the ordinary generalized geometric-arithmetic (OGA) index, first and second Gourava indices, first and second hyper-Gourava indices, general Randic´ index RγG,for γ=±1,
Muhammad Haroon Aftab, Muhammad Rafaqat, M. Hussain, Tariq Zia   +3 more
doaj   +1 more source

Encoding Multi-Resolution Brain Networks Using Unsupervised Deep Learning

, 2017
The main goal of this study is to extract a set of brain networks in multiple time-resolutions to analyze the connectivity patterns among the anatomic regions for a given cognitive task.
Alchihabi, Abdullah, Antsaklis, Panos, Gupta, Vijay, Rahnama, Arash, Vural, Fatos T. Yarman   +4 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source