Results 281 to 290 of about 64,299 (311)
Some of the next articles are maybe not open access.
Biology of the Cell, 2002
Summry— Connexin channels clustered at gap junctions are obligatory attributes of all macroscopic endocrine and exocrine glands investigated so far and also connect most types of cells which produce secretory products in other tissues. Increasing evidence indicates that connexins, and the cell‐to‐cell communications that these proteins permit ...
Serre Beinier, Véronique +8 more
openaire +3 more sources
Summry— Connexin channels clustered at gap junctions are obligatory attributes of all macroscopic endocrine and exocrine glands investigated so far and also connect most types of cells which produce secretory products in other tissues. Increasing evidence indicates that connexins, and the cell‐to‐cell communications that these proteins permit ...
Serre Beinier, Véronique +8 more
openaire +3 more sources
Connexin-30 Deletion Analysis in Connexin-26 Heterozygotes
Genetic Testing, 2003Mutations in the Connexin-26 gene (Cx 26, GJB2) are the most common cause of hereditary nonsyndromic sensorineural hearing loss (SNHL). DNA analysis of the Cx 26 gene in deaf or hard-of-hearing individuals frequently demonstrates heterozygosity despite the fact that most mutations are known to be recessive. A 342-kb deletion in a gene adjacent to Cx 26,
Victoria A, Stevenson +2 more
openaire +2 more sources
Biology of the Cell, 2002
Summry— The hypothesis, that gap junctional intercellular communication plays a key role in carcinogenesis and more generally in growth control was formulated nearly 40 years ago. From this time, data accumulated, showing that this type of communication is frequently decreased or absent in cells treated with tumor promoting agents, among transformed ...
openaire +2 more sources
Summry— The hypothesis, that gap junctional intercellular communication plays a key role in carcinogenesis and more generally in growth control was formulated nearly 40 years ago. From this time, data accumulated, showing that this type of communication is frequently decreased or absent in cells treated with tumor promoting agents, among transformed ...
openaire +2 more sources
2006
Remodeling of the vascular wall plays a central role in many physiological processes, but also in the pathogenesis of cardiovascular diseases such as atherosclerosis and restenosis. Atherosclerosis represents the major cause of death and disability in adult populations of Western societies.
Chadjichristos, Christos +2 more
openaire +3 more sources
Remodeling of the vascular wall plays a central role in many physiological processes, but also in the pathogenesis of cardiovascular diseases such as atherosclerosis and restenosis. Atherosclerosis represents the major cause of death and disability in adult populations of Western societies.
Chadjichristos, Christos +2 more
openaire +3 more sources
Connexins and β-cell functions
Diabetes Research and Clinical Practice, 2013Proper functioning of pancreatic islets requires that numerous β-cells are properly coordinated. With evolution, many mechanisms have converged, which now allow individual β-cells to sense the state of activity of their neighbors as well as the changes taking place in the extracellular medium, and to regulate accordingly their own function.
Cigliola Valentina +3 more
openaire +3 more sources
Connexins and Cardiac Arrhythmias
2006During cardiac remodeling, impulse conduction in the heart is altered by changes in excitability, electrical coupling, and tissue architecture. The impairment of normal impulse conduction is one of the factors that increases the propensity for arrhythmias. This chapter focuses on the relationship between electrical coupling between ventricular myocytes
van Rijen, Harold V. M. +4 more
openaire +3 more sources
Endothelial Connexin 37, Connexin 40, and Connexin 43 Respond Uniquely to Substrate and Shear Stress
Endothelium, 2007Endothelial connexins have been linked to atherosclerosis and hypertension; however, little is know about their sensitivity to stimuli and individual functions. This study investigates the responses of endothelial connexin 37, connexin 40, and connexin 43 (Cx37, Cx40, and Cx43) to shear stress and substrate.
Tiffany L, Johnson, Robert M, Nerem
openaire +2 more sources
2010
Non-healing cutaneous wounds such as leg ulcers are a major cause of morbidity and mortality, especially in diabetes. Currently 67% of ulcers fail to respond to treatment after 20 weeks of care, and are a substantial time and cost burden. Recent studies suggest significant increases in skin wound healing rates occur by reduction of connexin (Cx ...
Wright, Catherine, Martin, Patricia
openaire +1 more source
Non-healing cutaneous wounds such as leg ulcers are a major cause of morbidity and mortality, especially in diabetes. Currently 67% of ulcers fail to respond to treatment after 20 weeks of care, and are a substantial time and cost burden. Recent studies suggest significant increases in skin wound healing rates occur by reduction of connexin (Cx ...
Wright, Catherine, Martin, Patricia
openaire +1 more source
Trends in molecular medicine
Neuropathic pain is a chronic debilitating condition caused by nerve injury or a variety of diseases. At the core of neuropathic pain lies the aberrant neuronal excitability in the peripheral and/or central nervous system (PNS and CNS). Enhanced connexin expression and abnormal activation of connexin-assembled gap junctional channels are prominent in ...
Su, Yixun +2 more
openaire +1 more source
Neuropathic pain is a chronic debilitating condition caused by nerve injury or a variety of diseases. At the core of neuropathic pain lies the aberrant neuronal excitability in the peripheral and/or central nervous system (PNS and CNS). Enhanced connexin expression and abnormal activation of connexin-assembled gap junctional channels are prominent in ...
Su, Yixun +2 more
openaire +1 more source