Results 91 to 100 of about 195,400 (281)
Identification of the Calmodulin Binding Domain of Connexin 43 [PDF]
Journal of Biological Chemistry, 2007 Calmodulin (CaM) has been implicated in mediating the Ca(2+)-dependent regulation of gap junctions. This report identifies a CaM-binding motif comprising residues 136-158 in the intracellular loop of Cx43. A 23-mer peptide encompassing this CaM-binding motif was shown to bind Ca(2+)-CaM with 1:1 stoichiometry by using various biophysical approaches ...
Yanyi Chen +8 more
openaire +2 more sources
Role of astroglial hemichannels and pannexons in Memory and Neurodegenerative diseases
Frontiers in Integrative Neuroscience, 2016 Under physiological conditions, astroglial hemichannels and pannexin channels allow the release of gliotransmitters from astrocytes. These gliotransmitters are critical in modulating synaptic transmission, plasticity and memory.
Juan Andrés Orellana +3 more
doaj +1 more source
Glia, EarlyView.Cell culture studies show disrupted astrocyte physiology in the leukodystrophy MLC. Are intact astrocytes similarly affected? This study on astrocytes in MLC mouse brain slices confirms and extends in vitro studies on altered astrocyte physiology. ABSTRACT Electrical signaling, driven by ion fluxes between intra‐ and extracellular compartments, is ...
Sven Kerst +5 more
wiley +1 more source
Synchronization in Electrically Coupled Neural Networks [PDF]
arXiv, 2006 In this report, we investigate the synchronization of temporal activity in an electrically coupled neural network model. The electrical coupling is established by homotypic static gap-junctions (Connexin 43). Two distinct network topologies, namely: {\em sparse random network, (SRN)} and {\em fully connected network, (FCN)} are used to establish the ...
arxiv
Molecular Nutrition &Food Research, EarlyView.In this study we utilized proteomic profiling to investigate mechanisms linked to the cancer‐inhibitory effect of cranberry proanthocyanidins (CPACs) on reflux‐induced esophageal adenocarcinoma in a rat model. The results indicate that CPAC inhibits cancer through targeting multiple hallmarks of cancer known to be dysregulated in progression to ...
Yun Zhang +7 more
wiley +1 more source
Influence of Berberine on Cisplatin Antineoplastic Effect in A549 Cells
Chinese Journal of Lung Cancer, 2015 Background and objective Cisplatin is a standard first-line chemotherapeutic agents for treating advanced non-small cell lung cancer. Unfortunately, the clinical application cisplatin is restricted because it induces serious adverse reaction.
Guojun JIANG +4 more
doaj +1 more source
The Role of Gap Junctions in Adrenal Gland Function [PDF]
, 2004 This thesis explores the theory that gap junctions play a role in adrenocortical homeostasis and function. To test this hypothesis, gap junction mediated communication was investigated in the intact adrenal gland.
Davis, Kevin T.
core +1 more source
Cx43-hemichannel function and regulation in physiology and pathophysiology: insights from the bovine corneal endothelial cell system and beyond [PDF]
, 2014 Intercellular communication in primary bovine corneal endothelial cells (BCECs) is mainly driven by the release of extracellular ATP through Cx43 hemichannels.
Bultynck, Geert +4 more
core +2 more sources
Neuroprotection, EarlyView.Cerebral ischemia is a serious neurological disease that mainly leads to pathological changes such as mitochondrial dysfunction, oxidative stress and iron death. Mitochondria play a key role in the regulation of cellular energy metabolism and oxidative stress, and their damage can lead to mitochondrial damage, reduced adenosine triphosphate production,
Shuchen Meng +9 more
wiley +1 more source