Results 161 to 170 of about 195,400 (281)

Specialized Pro‐Resolving Mediators as Emerging Players in Cardioprotection: From Inflammation Resolution to Therapeutic Potential

open access: yesActa Physiologica, Volume 241, Issue 7, July 2025.
ABSTRACT Aim Timely myocardial reperfusion is essential for restoring blood flow to post‐ischemic tissue, thereby reducing cardiac injury and limiting infarct size. However, this process can paradoxically result in additional, irreversible myocardial damage, known as myocardial ischemia–reperfusion injury (MIRI).
Anna De Bartolo   +3 more
wiley   +1 more source

Effects of Connexin 43 Inhibition in an Ovalbumin-induced Mouse Model of Asthma

open access: yesIranian Journal of Allergy, Asthma and Immunology, 2018
Connexion 43 (Cx43), a gap junction protein, is expressed abundantly in the airway and has been implicated in the pathogenesis of asthma. However, the effects of blocking Cx43 in asthma remain unclear.
Jian-Qiang Huang   +5 more
doaj  

Classical Yang-Baxter equation and the $A_{\infty}$-constraint [PDF]

open access: yesarXiv, 2000
We show that elliptic solutions of the classical Yang-Baxter equation can be obtained from triple Massey products on elliptic curve. We introduce the associative version of this equation which has two spectral parameters and construct its elliptic solutions. We also study some degenerations of these solutions.
arxiv  

High‐throughput screening identifies bazedoxifene as a potential therapeutic for dysferlin‐deficient limb girdle muscular dystrophy

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 13, Page 2930-2949, July 2025.
Abstract Background and Purpose Limb‐girdle muscular dystrophy R2 (LGMD R2) is a rare genetic disorder characterised by progressive weakness and wasting of proximal muscles. LGMD R2 is caused by the loss of function of dysferlin, a transmembrane protein crucial for plasma membrane repair in skeletal muscles.
Celine Bruge   +10 more
wiley   +1 more source

Two symmetry problems in potential theory [PDF]

open access: yesElec. J. Diff eqns, # 43, v. 2001, 2001
We consider two eliiptic overdetermined boundary value problems. There are variants on J. Serrin's 1971 classical results and having the same conclusion that the domains should be forcibly Euclidean balls.
arxiv  

Blockade of P2X7 receptors preserves blood retinal barrier integrity by modulating the plasmalemma vesicle‐associated protein: Implications for diabetic retinopathy

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 12, Page 2603-2620, June 2025.
Background and Purpose Plasmalemma vesicle‐associated protein (PLVAP) regulates transcytosis in vascular endothelial cells. PLVAP expression is increased in pathological conditions, such as diabetic retinopathy. P2X7 receptor antagonists have been shown to preserve blood‐retinal barrier (BRB) integrity.
Chiara Bianca Maria Platania   +16 more
wiley   +1 more source

Chlorpromazine overcomes temozolomide resistance in glioblastoma by inhibiting Cx43 and essential DNA repair pathways

open access: yesJournal of Translational Medicine
Background In the fight against GBM, drug repurposing emerges as a viable and time-saving approach to explore new treatment options. Chlorpromazine, an old antipsychotic medication, has recently arisen as a promising candidate for repositioning in GBM ...
Paola Matarrese   +5 more
doaj   +1 more source

Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture [PDF]

open access: green, 2001
Jorge E. Contreras   +8 more
openalex   +1 more source

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