Results 141 to 150 of about 43,790 (245)

Connexin 43 peptidic medicine for glioblastoma stem cells

EBioMedicine, 2021
Zhi Sheng
doaj   +1 more source

Biomaterial Physical Cues as Gene Regulators for Cellular Agriculture

Advanced Genetics, Volume 7, Issue 2, June 2026.
This review elucidates how biomaterial physical cues—ranging from matrix stiffness to remote electromagnetic fields—serve as extrinsic regulators of gene expression in cellular agriculture. By identifying central mechanotransduction pathways that bridge physical inputs to genetic remodeling, the authors propose the “Material Genome” concept: a ...
Jianuo Liu, Ye Liu
wiley   +1 more source

Chlorpromazine overcomes temozolomide resistance in glioblastoma by inhibiting Cx43 and essential DNA repair pathways

Journal of Translational Medicine
Background In the fight against GBM, drug repurposing emerges as a viable and time-saving approach to explore new treatment options. Chlorpromazine, an old antipsychotic medication, has recently arisen as a promising candidate for repositioning in GBM ...
Paola Matarrese, Michele Signore, Barbara Ascione, Giulia Fanelli, Marco G. Paggi, Claudia Abbruzzese   +5 more
doaj   +1 more source

A Cationic Block Co‐Polymer for Gene Delivery in the Posterior Segment of the Eye

Journal of Biomedical Materials Research Part A, Volume 114, Issue 5, May 2026.
ABSTRACT Diseases of the back of the eye such as neovascular age‐related macular degeneration (nAMD) are vision threatening and treatment is burdensome for patients, often requiring ocular injections every other month. Injection risks and logistics lower patient compliance; however, even patients receiving optimal treatment can deteriorate.
Amber Monteiro, Odunayo O. Mugisho, Antonio de Souza, Lina Liu, Yosra Agban, Priyanka Agarwal, Avik Shome, Ilva D. Rupenthal, Heather Sheardown   +8 more
wiley   +1 more source

GAP JUNCTION: Emphasis on Connexin 43

Acta Scientiae et Technicae
The junctions of the cell are complex structures that play a fundamental role in cellular communication. They are morphologically distinct and are divided into occlusion junctions, adherens junctions and gap junctions. This review has the objective of providing the main information about the gap junctions demonstrating its components and highlighting ...
Gabriella Oliveira Alves Moreira de Carvalho, Olga Maria De Jesus Souza, Fabio Da Silva de Azevedo Fortes   +2 more
openaire   +1 more source

Congenital CMV and Hearing Loss—How Does it Happen and How to Prevent it

Reviews in Medical Virology, Volume 36, Issue 3, May 2026.
ABSTRACT Congenital cytomegalovirus (cCMV) is found worldwide and significantly contributes to permanent childhood hearing loss. CMV has been known to cause sensorineural hearing loss (SNHL) for more than half a century, and CMV‐related hearing loss has consistently been present in all childhood populations where infants with cCMV have been identified ...
Karen B. Fowler
wiley   +1 more source

Fluorescence Guided Raman Spectroscopy enables the training of robust support vector machines for the detection of tumour marker proteins

Scientific Reports
Raman spectroscopy provides comprehensive biochemical information on a sample’s composition, yet it is often used to analyze aggregated spectra rather than specific shifts.
Johannes Reifenrath, Benjamin Gardner, Alexander Gigler, Friederike Liesche-Starnecker, Suzy Eldershaw, Nick Stone, Jürgen Schlegel   +6 more
doaj   +1 more source

Mitochondrial Transfer in the Tumor Microenvironment

Cancer Science, Volume 117, Issue 5, Page 1189-1198, May 2026.
Mitochondria are actively exchanged among tumor, immune, stromal, and neuronal cells within the tumor microenvironment. Such transfer rewires tumor metabolism, promotes immune evasion, and drives therapy resistance. Targeting mitochondrial transfer or harnessing mitochondrial transplantation represents a promising strategy to restore antitumor immunity
Ryo Omae, Takamasa Ishino, Yosuke Togashi   +2 more
wiley   +1 more source

Small Cell Lung Cancer Establishes a Metabolic Autocrine Mechanism Through Active Extracellular ATP Transport

Cancer Science, Volume 117, Issue 5, Page 1333-1345, May 2026.
Small cell lung cancer (SCLC) actively exports ATP through PANX1 channels, triggering P2RX7‐mediated autocrine signaling and promoting tumor proliferation. Inhibition of PANX1 or P2RX7 disrupts this loop and suppresses tumor growth. ABSTRACT Small cell lung cancer (SCLC) is an aggressive malignancy with a 5‐year survival rate of less than 7%.
Takeshi Tsuruda, Manabu Kodama, Keiichi I. Nakayama   +2 more
wiley   +1 more source

T Cell Receptor Repertoires Across the Continuum of Vascular, Myocardial, and Age‐Related Diseases

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT Cardiovascular diseases (CVD) are shaped by a complex interplay with immune mechanisms. In particular, the distinct roles of antigen‐specific T cell mechanisms are emerging as critical determinants across a broad spectrum of conditions, ranging from atherosclerosis, myocardial infarction (MI), heart failure (HF), and myocarditis. Because these
Leon Richter, João Dias‐Ferreira, Gustavo Campos Ramos, DiyaaElDin Ashour   +3 more
wiley   +1 more source