Results 151 to 160 of about 369,208 (341)
The Ta-Da Series: presentation of a technique and its use in generating a series of surprising designs [PDF]
, 2006 Surprise is an emotion that is used very explicitly in personal interactions and in narrative media, yet it is not used in the same way within design. This case study presents a technique devised and used to apply the results of theoretical research on ...
Grimaldi, Silvia
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Is shadow banking really banking? [PDF]
To those who don't know, the term "shadow banking" probably has a negative connotation. This primer draws parallels between what has been termed the shadow banking sector and the traditional banking sector—showing that they are similar in many ways.Banks
Bryan J. Noeth, Rajdeep Sengupta
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Cartesian Certainty and the Infinity of the Will [PDF]
, 2004 This paper interprets Descartes\u27 conception of certainty as most fundamentally a function of the human will, controlling the cognitive encounter with the ...
Cosgrove, Joseph K.
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Typothesis: A Study of Warde\u27s Crystal Goblet, Leeuwen\u27s Typographic Meaning and How it Relates to the Bible [PDF]
, 2011 The way readers interpret the written word is changing. We look for information almost as much in between the lines as we do in the words themselves. The internet and its tools offer ways for readers to engage the text like never before — can the printed
Mercer, Ryan
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Theoretical approach of branding from a semiotic perspective [PDF]
, 2018 This paper outlines the importance of the world of signs and symbols relating to brand management. We will explore the traditional semiotics authors and how those have been influenced other academics who have researched branding from a semiotic ...
Sanz-Marcos, Paloma
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source