Results 111 to 120 of about 27,235 (248)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
O ÍNDIO BRASILEIRO E O HOMEM NATURAL: UMA CRÍTICA ANTROPOLÓGICA
Espaço Ameríndio, 2008 : The concept of the noble savage from Rousseau, as interpreted in O Índio Brasileiro e a Revolução Francesa is a text that adresses the nature/culture dichotomy, valuable for anthropological scrutiny.
ROSA VIRGÍNIA MELO
doaj
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Thinking with Irigaray: On Asian Women as Objects of Conquest and Exchange
, 2017 Elaine Lazaro
openalex +1 more source
Stefan Rinke, Conquistadoren und Azteken. Cortés und die Eroberung Mexikos
Nuevo mundo - Mundos Nuevos, 2023 Daniel Rojas
doaj +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Practical strategies for achieving system change in the US: lessons and insights from the CONQUEST quality improvement programme. [PDF]
Prim Health Care Res DevEvans A +23 more
europepmc +1 more source