Results 61 to 70 of about 69,612 (292)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
, 1991 Born in England, John Conquest followed the piper to Austin and launched his journal Music City Texas in 1989 to document the burgeoning live performance industry—especially the alt-country and singer-songwriter genres.
core
Revista Chilena de Literatura, 2010 El presente artículo proporciona una lectura actualizada de las llamadas ‘novelas históricas’ o ‘novelas de ciudad’ de Carlos Droguett. En particular, sus novelas centradas en la conquista y fundación de la ciudad de Santiago (100 gotas de sangre y 200 ...
Roberto Suazo Gómez
doaj
El hedor en la Nueva España: sensibilidad olfativa ante el fenómeno de la otredad (siglo XVI)
Historia CríticaObjective/Context: This article aims to analyze the olfactory descriptions of blood, the Indigenous, and their idols in sacrificial narratives in four early modern American sources (sixteenth century): Letters of Relation by Hernán Cortés, The Vision of ...
Ingrid Sánchez Téllez
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
, 1995 Born in England, John Conquest followed the piper to Austin and launched his journal Music City Texas in 1989 to document the burgeoning live performance industry—especially the alt-country and singer-songwriter genres.
core
Études romanes de Brno, 2018 En los capítulos CLXXXV-CLXXXVIII (185 y 188) de Historia verdadera de la conquista de la Nueva España (1632) Bernal Díaz del Castillo describe a la misma mujer —Juana de Mansilla— como hechicera y como matrona romana.
Silvia Ruiz Tresgallo
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
, 2012 Born in England, John Conquest followed the piper to Austin and launched his journal Music City Texas in 1989 to document the burgeoning live performance industry—especially the alt-country and singer-songwriter genres.
core +1 more source