Results 71 to 80 of about 314,852 (352)

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Certainty, Probability, and Stalin’s Great Party Purge [PDF]

open access: yes, 2004
In 1935, Stalin decided to purge his own party to consolidate power in the Soviet government. Since the inception of historical research about this event, a debate has developed regarding the number of arrests and deaths of Soviets ordered by Stalin ...
Homkes, Brett
core   +2 more sources

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

CONQUISTA Y FUNDACIÓN DE LA CIUDAD TERRENA: EL NACIMIENTO DE SANTIAGO EN LA NARRATIVA DE CARLOS DROGUETT

open access: yesRevista Chilena de Literatura, 2010
El presente artículo proporciona una lectura actualizada de las llamadas ‘novelas históricas’ o ‘novelas de ciudad’ de Carlos Droguett. En particular, sus novelas centradas en la conquista y fundación de la ciudad de Santiago (100 gotas de sangre y 200 ...
Roberto Suazo Gómez
doaj  

La construcción política de la hechicera: discursos de género y poder en "El caso de Juana de Mansilla" de Bernal Díaz del Castillo

open access: yesÉtudes romanes de Brno, 2018
En los capítulos CLXXXV-CLXXXVIII (185 y 188) de Historia verdadera de la conquista de la Nueva España (1632) Bernal Díaz del Castillo describe a la misma mujer —Juana de Mansilla— como hechicera y como matrona romana.
Silvia Ruiz Tresgallo
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

What Good Can There Be In This Kind of Human? Spanish Justification for the Conquest of the Americas

open access: yes, 2020
The Spanish conquest of the Americas was one of the most brutal episodes in human history. Entire cultures of American natives were suppressed, murdered, raped, and enslaved by Spanish conquistadors on an incessant quest for precious metals and other ...
Pittenger, John R.
core  

The aryans and the ancient system of caste [PDF]

open access: yes, 2015
Over the last century or two, the dominant accounts of the caste system have looked for its roots in the ancient history of India. More precisely scholars have linked the origin of the caste system to the invasion of a Sanskrit speaking people, the ...
Keppens, Marianne
core   +2 more sources

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