Results 101 to 110 of about 6,343 (253)

Population stratification and genetic association studies in South Asia

, 2005
Population stratification and its influence on genetic association studies is a controversial topic. Although it has been suggested that stratification is unlikely to bias the results of association studies conducted in developed countries, convincing ...
Bittles, Alan, Bittles, A.H.
core   +1 more source

Does consanguinity increase the risk of bronchial asthma in children?

Annals of Thoracic Medicine, 2008
There is a high prevalence of consanguinity and bronchial asthma in Saudi Arabia. The objective of this study is to explore the effect of parental consanguinity on the occurrence of bronchial asthma in children.
El Mouzan Mohammad, Al Salloum Abdullah, Al Herbish Abdullah, Al Omar Ahmad, Qurachi Mansour   +4 more
doaj  

De Novo Designed Minibinders Targeting the GDF15–GFRAL Axis Reverse Cancer Cachexia and Restore Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐derived GDF15 drives cancer cachexia and suppresses antitumor immunity. Here, de novo designed minibinders targeting the GDF15–GFRAL interface achieve picomolar affinity and potent pathway blockade. The minibinders alleviate cachexia, restore CD8+ T‐cell infiltration, enhance anti–PD‐1 responsiveness, and provide survival benefits across tumor ...
Haitao Wang, Tianzhen Hua, Meiling Wang, Bingbing Meng, Yue Zhang, Chengxu Jiang, Yunhe Gao, Hongqi Yang, Jian Bo   +8 more
wiley   +1 more source

CONSANGUINITY;

The Professional Medical Journal, 2017
Introduction: The epidemiological literature is inconsistent in its findings onassociation of parental consanguinity & birth outcomes. Research studies rarely look into thekin relationship of the spouses as a possible risk factor for reproductive wastage includingintra uterine deaths (IUDs). Objective: To assess the effect of parental consanguinity
Dr. Khalida Naz Memon, Prof. Aneela Atta Ur Rahman   +1 more
openaire   +2 more sources

The effect of consanguinity on neonatal outcomes and health [PDF]

, 2014
Consanguineous marriages constitute a significant fraction of marriages worldwide and confer a major public health concern on newborns. In addition to the risk of acquiring a recessive genetic disease, the offspring of consanguineous parents are ...
Abbas, Hussein A., Yunis, Khalid A.
core   +1 more source

Beyond Potency: Emerging Determinants and Optimization Strategies Enhancing Therapeutic Efficacy of Adult Stem Cells

Advanced Science, EarlyView.
Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim, Yun Jae Jung, Hwa‐Yong Lee   +2 more
wiley   +1 more source

94. How relative risk of cancer from consanguinity and consanguinity rate affect number of cancer cases in United Arab Emirates

, 2003
AimMarriage between relatives is common in many countries of the world. In the United Arab Emirates (UAE), 50% of all marriages are consanguineous. Consanguinity increases chances of gene homozygousity, and homozygousity of cancer-susceptibility genes ...
Denic, S., Awad, M., J. Milenkovic, Milenkovic, J., F. Khatib, Khatib, F., M. Awad, S. Denic   +7 more
core   +1 more source

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, EarlyView.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source

Consanguineous marriages, pearls and perils: Geneva International Consanguinity Workshop Report [PDF]

, 2011
Approximately 1.1 billion people currently live in countries where consanguineous marriages are customary, and among them one in every three marriages is between cousins.
van Duijin, C., Kate, Leo P. Ten, Kate, L.P. ten, Sharif, SM, Luigi Luca Cavalli-Sforza, Karbani, GA, Bennett, R.L, Alison Shaw, Romeo, G, Morris, MA, Emmanuelle Ranza-Boscardin, Alwasiyah, Mohamed K., Lorraine Gwanmesia, Marieke E. Teeuw, Bennett, Robin L., Ajaz, Mubasshir, Teeuw, Marieke E., Arsenault, S., Cornelia van Duijn, Megarbane, Andre, ten Kate, LP, Corry, Peter, Emmanouil Dermitzakis, Mohamed K. Alwasiyah, Pippucci, Tommaso, Sophie Dahoun, Antonarakis, Stylianos, Ayad Alkalamchi, Antonarakis, SE, Antonarakis, S.E., Dermitzakis, Emmanouil, Temtamy, S., Ajaz, M, Gwanmesia, L, Hamamy, Hanan, Pippucci, T., Bonnefin, Melissa, Karbani, Gulshan A., Dhekra Alnaqeb, Steve Arsenault, Bruno Reversade, Alwasiyah, MK, Fokstuen, S., Karbani, G.A., M.D. Peter Corry, Arsenault, Steve, Bathija, H., Bennett, RL, Reversade, B., Dahoun, Sophie, Mostafavi, M., Zlotogora, Joel, Alnaqeb, Dhekra, Megarbane, A., Anwer, N., Fokstuen, Siv, Bonnefin, M, Cavalli-Sforza, LL, Ranza-Boscardin, E, Engel, E., Morris, Michael A., Dahoun, S, Mubasshir Ajaz, Duijn, C. van, Robin L. Bennett, Bathija, H, Ranza-Boscardin, Emmanuelle, Hanan Hamamy, Andre Megarbane, Dermitzakis, E, Bottani, Armand, Michael A. Morris, Cavalli-Sforza, Luigi Luca, Temtamy, S, Giovanni Romeo, Bottani, A, Morris, M.A., Bathija, Heli, Eric Engel, Engel, E, Ranza-Boscardin, E., Cavalli-Sforza, L.L., Mostafavi, Maryam, Alkalamchi, Ayad, Megarbane, A, Awwad, R., Romeo, Giovanni, Heli Bathija, Mostfavi, M., Anwer, Nawfal, Romeo, G., Reversade, Bruno, Alkalamchi, A., Hamamy, H, Siv Fokstuen, Saghira M. Sharif, Rawan Awwad, Alnaqeb, D, Morris, Michael Andréw, Alnaqeb, D., Joel Zlotogora, Melissa Bonnefin, Shaw, Alison, Bottani,, Temtamy, Samia, Nawfal Anwer, Pippucci, T, Bonnefin, M., Corry, P., Shaw, A, Dahoun, S., Zlotogora, J, Bittles, AH, van Duijn, C., van Duijn, Cornelia, Awwad, Rawan, Karbani, G.A, Alkalamchi, A, Gwanmesia, Lorraine, Samia Temtamy, Bottani, A., Leo P. Ten Kate, Zlotogora, J., Teeuw, M.E., Duijn, Cornelia, Gulshan A. Karbani, Hamamy, H., Alwasiyah, M.K., Antonarakis, Stylianos E., Corry, P, Teeuw, ME, Armand Bottani, Reversade, B, Alan H. Bittles, Mostafavi, M, Sharif, S.M., Fokstuen, S, Shaw, A., Sharif, Saghira M., Awwad, R, Bennett, R.L., Bittles, A.H., Aglan, Mona S., Maryam Mostafavi, Arsenault, S, Ajaz, M., Stylianos E. Antonarakis, Engel, Eric, Mona S. Aglan, Anwer, N, Antonarakis, S.E, Aglan, MS, Ten Kate, L.P., Cavalli-Sforza, L.L, Gwanmesia, L., Bittles, Alan H., Aglan, M.S., Dermitzakis, E., Tommaso Pippucci   +158 more
core   +1 more source

Awareness of Premarital Screening and Genetic Counseling among Saudis and its Association with Sociodemographic Factors: a National Study

Journal of Multidisciplinary Healthcare, 2021
Walid A Al-Shroby,1,2 Suha M Sulimani,3 Sultana A Alhurishi,4 Maram E Bin Dayel,1 Nora A Alsanie,3 Najla J Alhraiwil1 1Evaluation & Impact Measurement Unit, Deputyship of Public Health, Ministry of Health, Kingdom of Saudi Arabia, Riyadh, Saudi ...
Al-Shroby WA, Sulimani SM, Alhurishi SA, Bin Dayel ME, Alsanie NA, Alhraiwil NJ   +5 more
doaj