Results 131 to 140 of about 1,670,289 (294)

Diagnostic accuracy of the CRS-R index in patients with disorders of consciousness

, 2019
peer reviewedObjective: To obtain a CRS-R index suitable for diagnosis of patients with disorders of consciousness (DOC) and compare it to other CRS-R based scores to evaluate its potential for clinics and research. Design: We evaluated the diagnostic
Martial, Charlotte, Filippini, Maria Maddalena, Annen, Jitka, Camille Chatelle, Leandro R. D. Sanz, Alice Barra, Aubinet, Charlène, Manon Carrière, Gosseries, Olivia, Laureys, Steven, Sanz, Leandro, Maddalena M. Filippini, Steven Laureys, Aurore Thibaut, Barra, Alice, Audrey Wolff, Charlène Aubinet, Wolff, Audrey, Olivia Gosseries, Chatelle, Camille, Jitka Annen, Estelle Bonin, Cassol, Helena, Thibaut, Aurore, Helena Cassol, Charlotte Martial, Bonin, Estelle, Carrière, Manon   +27 more
core   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Developing a data visualization tool for adults with disorders of consciousness: Qualitative analysis of user perspectives

Learning Health Systems
Introduction We report on the process of using a learning health systems (LHS) approach to design a data visualization dashboard to monitor the rehabilitation progress of patients with disorders of consciousness (DoC) after severe brain injury.
Alison M. Cogan, Shonali G. Gaudino, James E. Green II, Lewis E. Kazis, Mary D. Slavin, Jeffrey C. Schneider, Joseph T. Giacino   +6 more
doaj   +1 more source

The clinical complication scale of Fondazione Don Gnocchi for classifying clinical complications in patients with severe acquired brain injury: development and multicenter validation

Frontiers in Neurology
IntroductionPatients with severe acquired brain injury have a high risk of developing clinical complications that affect clinical outcome and rehabilitation program.
Anna Estraneo, Maria Rosaria Fiorentino, Tommaso Cibellis, Biagio Campana, Pietro Balbi, Valentina Carli, Elena Vatteroni, Guya Devalle, Francesco Mantelli, Mattia Villa, Alessandra Bianchi, Maria Concetta Costa, Marina Rossi, Angela Comanducci, Jorge Navarro, Alessandro Viganò, Agnese De Nisco, Francesca Draghi, Bahia Hakiki, Bahia Hakiki, Alfonso Magliacano   +20 more
doaj   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii   +14 more
wiley   +1 more source

Consciousness Disturbances Reported With Clindamycin Versus Cefazolin in Surgical Patients: A Global Pharmacovigilance Analysis Using VigiBase

Clinical and Translational Science
Clindamycin is a common β‐lactam substitute for surgical prophylaxis. Whether peri‐operative disturbances in consciousness are disproportionately reported with clindamycin in global pharmacovigilance data remains unclear.
Kazuki Nishida, Basile Chrétien, Hiroshi Morioka, Daigo Tamakoshi, Keita Hiraga, Tomoyuki Nakamura, Shigeyuki Matsui, Masahisa Katsuno, Yoshitaka Hara   +8 more
doaj   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

A rare case of severe pulmonary embolism revealed by consciousness disorders. [PDF]

AME Case Rep, 2020
Wang J, Yang D, Xiu Y, Huang X, Min X, Li J.   +5 more
europepmc   +1 more source

Paramagnetic Rim Lesions and Choroid Plexus Volume at Diagnosis Are Associated With Cognitive Progression Independent of Relapse and MRI Activity in Early Relapsing–Remitting Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) and choroid plexus (CP) enlargement reflect smoldering inflammation in multiple sclerosis. Their role in cognitive progression remains unexplored. Eighty‐seven early relapsing–remitting MS patients were enrolled at diagnosis and followed longitudinally.
Stefano Ziccardi, Damiano Marastoni, Agnese Tamanti, Pietro Biasi, Valentina Visani, Annalisa Colombi, Tom A. Fuchs, Monica Sicchieri, Chiara Eccher, Francesco Guarnaccia, Milena Calderone, Valentina Camera, Francesca Benedetta Pizzini, Roberta Magliozzi, Marco Castellaro, Massimiliano Calabrese   +15 more
wiley   +1 more source

A comparison of the P300 and PET in patients with disorders of consciousness in absence of response to command

, 2018
peer reviewedDetection and interpretation of signs of "covert command following" in patients with disorders of consciousness (DOC) remains a challenge for clinicians. In this study, we used a tactile P3-based BCI in 12 patients without behavioral command
Laureys, Steven, Wolff, Audrey, Blandiaux, Séverine, Annen, Jitka, Lejeune, Nicolas, Chatelle, Camille   +5 more
core