Results 141 to 150 of about 298,540 (337)

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Consciousness operates beyond the timescale for discerning time intervals: implications for Q-mind theories and analysis of quantum decoherence in brain [PDF]

, 2003
This paper presents in details how the subjective time is constructed by the brain cortex via reading packets of information called "time labels", produced by the right basal ganglia that act as brain timekeeper.
Georgiev, Danko
core  

Acute Disorders of Consciousness in Pediatric Severe Sepsis and Organ Failure: Secondary Analysis of the Multicenter Phenotyping Sepsis-Induced Multiple Organ Failure Study* [PDF]

, 2023
Christina Cheung, Kate F. Kernan, Robert A. Berg, Athena F. Zuppa, Daniel A. Notterman, Murray M. Pollack, David Wessel, Kathleen L. Meert, Mark W. Hall, Christopher J. L. Newth, John C. Lin, Allan Doctor, Tom Shanley, Tim Cornell, Rick Harrison, Russell Banks, Ron Reeder, Richard Holubkov, Joseph A. Carcillo, Ericka L. Fink   +19 more
openalex   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

A rare case of severe pulmonary embolism revealed by consciousness disorders. [PDF]

AME Case Rep, 2020
Wang J, Yang D, Xiu Y, Huang X, Min X, Li J.   +5 more
europepmc   +1 more source

Study of Brain Circadian Rhythms in Patients with Chronic Disorders of Consciousness and Healthy Individuals Using Microwave Radiometry

, 2022
Shevelev Oleg A., Petrova Marina V., Yuriev Mikhail Yu., Mengistu Elias M., Kostenkova Inna Z., Zhdanova Maria A., Vesnin Sergey G., Goryanin Igor   +7 more
openalex   +1 more source

Needs and Quality of Life of Caregivers of Patients with Prolonged Disorders of Consciousness [PDF]

, 2023
Olivia Gosseries, Caroline Schnakers, Audrey Vanhaudenhuyse, Charlotte Martial, Charlène Aubinet, Vanessa Charland‐Verville, Aurore Thibaut, Jitka Annen, Didier Ledoux, Steven Laureys, Charlotte Grégoire   +10 more
openalex   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Merleau-Ponty and the Foundations of Psychopathology [PDF]

, 2019
Fernandez, Anthony Vincent
core   +1 more source