Results 71 to 80 of about 1,670,289 (294)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Psilocybin increases optimistic engagement over time: computational modelling of behaviour in rats

Translational Psychiatry
Psilocybin has shown promise as a novel pharmacological intervention for treatment of depression, where post-acute effects of psilocybin treatment have been associated with increased positive mood and decreased pessimism.
Elizabeth L. Fisher, Ryan Smith, Kyna Conn, Andrew W. Corcoran, Laura K. Milton, Jakob Hohwy, Claire J. Foldi   +6 more
doaj   +1 more source

Apomorphine therapy for patients with disorders of consciousness: a multimodal open-label study

, 2021
peer reviewedIntroduction: Apomorphine, a repurposed dopaminergic drug, is a promising therapy to improve the recovery of patients with disorders of consciousness (DOC), with a postulated action on the mesocircuit.
Farber, Neal, Sala, Arianna, Thibaut, Aurore, Laureys, Steven, Gosseries, Olivia, Sanz, Leandro, Bonin, Estelle, Lejeune, Nicolas, Panda, Rajanikant, Dikenstein, David   +9 more
core  

Severe Brain Damage: Coma and Related Disorders of Consciousness

, 2022
peer reviewedProgress in intensive care efforts has increased the number of patients who survive severe acute brain damage. Although the majority of these patients recover from coma within the first days after the insult, some permanently lose all brain ...
Gosseries, Olivia, Laureys, Steven
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Breakdown of effective information flow in disorders of consciousness: Insights from TMS-EEG

Brain Stimulation
Background: The complexity of the neurophysiological mechanisms underlying human consciousness is widely acknowledged, with information processing and flow originating in cortex conceived as a core mechanism of consciousness emergence.
Yang Bai, Li Yang, Xiangqiang Meng, Ying Huang, Qijun Wang, Anjuan Gong, Zhen Feng, Ulf Ziemann   +7 more
doaj   +1 more source

Central nervous system manifestations in COVID‐19 patients: A systematic review and meta‐analysis

Brain and Behavior, 2021
Background At the end of December 2019, a novel respiratory infection, initially reported in China, known as COVID‐19 initially reported in China, and later known as COVID‐19, led to a global pandemic.
Shahrzad Nazari, Amirhossein Azari Jafari, Seyyedmohammadsadeq Mirmoeeni, Saeid Sadeghian, Mohammad Eghbal Heidari, Siavash Sadeghian, Farhad Assarzadegan, Seyed Mahmoud Puormand, Hamid Ebadi, Davood Fathi, Sahar Dalvand   +10 more
doaj   +1 more source

The Ethics in the Management of Patients with Disorders of Consciousness

Ethical reflection can play an important role in optimizing the management of patients with Disorders of Consciousness, for instance, revealing both good and bad practices.
Farisco, Michele,
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source