Results 81 to 90 of about 109,384 (305)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Anterior Cingulate Activity and the Self in Disorders of Consciousness [PDF]
, 2010 Objectives: The aim of this study was to investigate the relationship between medial cortical activation and the presence of self and consciousness in healthy subjects and patients with vegetative state and minimally conscious state using functional ...
Gong, Qiyong +9 more
core
Pain management in Disorders of Consciousness [PDF]
, 2018 Background: Patients with disorders of consciousness (DOC) are unable to communicate about their feelings and therefore they cannot express potential painful sensation.
Bornheim, Stephen +9 more
core +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Psychedelics as a treatment for disorders of consciousness [PDF]
, 2019 Based on its ability to increase brain complexity, a seemingly reliable index of conscious level, we proposetesting the capacity ofthe classic psychedelic, psilocybin,to increase conscious awarenessin patients with disorders of consciousness.We
Scott, Gregory +2 more
core +1 more source
Large-Scale Brain Simulation and Disorders of Consciousness. Mapping Technical and Conceptual Issues
Frontiers in Psychology, 2018 Modeling and simulations have gained a leading position in contemporary attempts to describe, explain, and quantitatively predict the human brain’s operations. Computer models are highly sophisticated tools developed to achieve an integrated knowledge of
Michele Farisco +4 more
doaj +1 more source
Functioning and Interpersonal Communication in a Victim of Carbon Monoxide Poisoning – A Case Study
Konteksty Pedagogiczne, 2020 Carbon monoxide poisoning leads to the destruction of nerve cells and results in late neurological symptoms. The article presents the clinical symptoms of carbon monoxide poisoning and related consciousness disorders. A case study is analyzed which shows
Anna Borzęcka
doaj +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Affect consciousness and eating disorders. Short term stability and subgroup characteristics [PDF]
, 2011 The aim of the study was to analyse differences in observer rated affect consciousness (AC) between subgroups of patients diagnosed with eating disorders (N=44; 30 with anorexia nervosa and 14 with bulimia nervosa), and a non-clinical group (N=40 ...
Gerhard Andersson +5 more
core +1 more source