Results 31 to 40 of about 1,479,782 (218)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
BiologyOpuntia stricta is a highly invasive cactus species that threatens arid and semiarid ecosystems worldwide. We identified the optimal species distribution model (SDM) to predict its global habitat suitability using three hierarchical frameworks: climate ...
Anil Poudel +4 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Being an Opposition MP in the 22nd Turkish Parliament
European Journal of Turkish Studies, 2015 This article analyzes the role and strategy of the main opposition (CHP) party’s MPs, their perceptions of their roles, their place in the legislative process and their relationship with their party in the 22nd Turkish Grand National Assembly.
Canan Aslan-Akman
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
PlantsAquatic ecosystems worldwide are increasingly threatened by invasive species, with water hyacinth [Eichhornia crassipes (Mart.) Solms] being among the most destructive aquatic weeds.
Prabhat Adhikari +4 more
doaj +1 more source
Movimentos sociais e democracia: a tensão necessária
Opinião Pública, 2012 O presente artigo analisa algumas das críticas feitas às teorias deliberativas da democracia, de forma a resgatar o conflito como componente determinante para o desenvolvimento das democracias contemporâneas.
Marcus Abilio Pereira
doaj +1 more source