Results 51 to 60 of about 1,479,782 (218)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

An Robust Secure Blockchain-Based Hierarchical Asynchronous Federated Learning Scheme for Internet of Things

IEEE Access
Combining the Internet of Things (IoT) and federated learning (FL) is a trend. In addition to privacy risks, a long-term operating IoT always faces a hierarchical environment, heterogeneous nodes, and occasional communication and node failures ...
Yonghui Chen, Linglongyan, DaxiangAI
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Executive summary: indonesian guidelines on polycystic ovary syndrome management [PDF]

Obstetrics & Gynecology Science
Objective Polycystic ovary syndrome (PCOS) is a gynecological, endocrine condition characterized by ovulatory disorders, clinical or biochemical hyperandrogenism, and polycystic ovarian morphology.
Mila Maidarti, Achmad Kemal Harzif, Amalia Shadrina, Nafi'atul Ummah, Wiryawan Permadi,   +5 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

La «culture de l'assemblée» dans le 15M

Swiss Journal of Sociocultural Anthropology
En Espagne, le mouvement du 15M s’est organisé en assemblées autogérées sur les places publiques, dépassant les cercles militants auxquels ces pratiques étaient jusque-là confinées.
Héloïse Nez
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Expert Consensus on the Clinical Utilization of Ketamine and Its Isomers in Intensive Care Units

Intensive Care Research
Analgesia and sedation are important treatment strategies in the intensive care unit (ICU). Due to the opioid crisis, opioid-sparing medications become the focus of clinical studies.
Zhiyong Peng, Tongwen Sun, Xijing Zhang, Haibo Zhang   +3 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

A Consensus-Based Current Sharing Algorithm for Energy Storage Systems: An Application to Aeronautic Microgrids

IEEE Access
More Electric Aircraft (MEA) and All Electric Aircraft (AEA) require advanced autonomous electric Energy Management Systems (EMS) onboard the aircraft. The aircraft electric network can be considered as an islanded microgrid, and as such some approaches ...
Giacomo Canciello, Antonio Russo, Alberto Cavallo   +2 more
doaj   +1 more source