Results 151 to 160 of about 600,349 (318)

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

ITGB1 Regulates Triple‐Negative Breast Cancer Development by Modulating the Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer‐immune crosstalk in the TME is imperative for developing efficacious immunotherapy.
Nuozi Song, Siqi Chen, Lei Wang, Jessica Dang, Xu Cao, Stephanie Singh, Lu Yang, Jinhui Wang, Steven T. Rosen, Yingyu Wang, Chun‐Wei D. Chen, Cheng Zhang, Mingye Feng   +12 more
wiley   +1 more source

Seele's New Anti-ASIC Consensus Algorithm with Emphasis on Matrix Computation [PDF]

, 2019
Luke Zeng, Shawn Xin, Avadesian Xu, Thomas W.S. Pang, Tim D. Yang, Maolin Zheng   +5 more
openalex   +1 more source

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

Advanced Science, EarlyView.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu, Bixia Wang, Xinya Jiang, Fangqing Zhang, Qianqian Huang, Xinyi Wu, Shuang Fan, Qi Zhang, Jingrui Zhou, Jianing Tang, Xiao‐Dong Mo, Yu Wang, Ying‐Jun Chang, Huidong Guo, Xiao‐Jun Huang   +14 more
wiley   +1 more source

APOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

Advanced Science, EarlyView.
A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li, Yike Chen, Daniel Western, Muhammad Ali, Menghan Liu, Katherine Gong, Ying Xu, Joseph Lowery, David M. Holtzman, Chloe Robins, John D. Eicher, Yen‐Ning Huang, ShiWei Liu, Tamina Park, Andrew J. Saykin, Kwangsik Nho, Mahdi Moqri, Richard C. Mohs, Amelia Farinas, Patricia Moran‐Losada, Hamilton Se‐Hwee Oh, Tony Wyss‐Coray, Carlos Cruchaga   +22 more
wiley   +1 more source

Practical Focus on American Diabetes Association/European Association for the Study of Diabetes Consensus Algorithm in Patients with Type 2 Diabetes Mellitus: Timely Insulin Initiation and Titration (Iran-AFECT)

, 2017
Mohammad E. Khamseh, Gholamreza Yousefzadeh, Zahra Banazadeh, Sahar Ghareh   +3 more
openalex   +1 more source

2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema [PDF]

, 2010
Tom Bowen, Marco Cicardi, Henriette Farkas, Konrad Bork, Hilary Longhurst, Bruce L. Zuraw, Emel Aygoeren-Pürsün, Timothy Craig, Karen Binkley, Jacques Hébert, Bruce Ritchie, Laurence Bouillet, Stephen Betschel, Della Cogar, John Mark Dean, Ramachand Devaraj, Azza Hamed, Palinder Kamra, Paul K. Keith, Gina Lacuesta, Eric Leith, Harriet D. Lyons, Sean R. Mace, Barbara Mako, Doris Neurath, Man‐Chiu Poon, Georges‐Étienne Rivard, R. Robert Schellenberg, Dereth Rowan, Anne Rowe, Donald Stark, Smeeksha Sur, Ellie Tsai, Richard Warrington, Susan Waserman, Rohan Ameratunga, Jonathan A. Bernstein, Janne Björkander, Kristylea Brosz, John Brosz, Anette Bygum, Teresa Caballero, Mike Frank, George Füst, George Harmat, Amin Kanani, W. Kreuz, Marcel Levi, Henry Li, Inmaculada Martinez‐Saguer, Dumitru Moldovan, István Nagy, Erik Waage Nielsen, Patrik Nordenfelt, Avner Reshef, E. Rusicke, Sarah Smith-Foltz, Peter Späth, Lilian Varga, Zhi Yu Xiang   +59 more
openalex   +1 more source

Spatio‐Temporal Proteomic Landscape Reveals Early Warning Signals of Esophageal Squamous Cell Carcinoma Progression

Advanced Science, EarlyView.
This study constructs a proteomic atlas of esophageal squamous cell carcinoma (ESCC) progression using esophageal biopsy samples. It identifies moderate dysplasia as the critical turning stage and a seven‐protein panel for early detection. Functionally, GBP6 loss promotes ESCC progression via cell cycle and epithelial‐mesenchymal transition (EMT ...
Xumiao Li, Jie Yuan, Min Gao, Jibin Liu, Qinqin Wang, Yaqi Zhang, Mingtao Cao, Xiaolin Hu, Hui Yang, Jun Li, Chen Li, Xiaoguang Li, Hui Wang   +12 more
wiley   +1 more source

The anatomy of a distributed predictive modeling framework: online learning, blockchain network, and consensus algorithm. [PDF]

JAMIA Open, 2020
Kuo TT.
europepmc   +1 more source

P321 Prognosis of intestinal Behcet’s disease according to the Korean consensus-based diagnostic algorithm [PDF]

, 2020
Yu Young Joo, Bong-Woo Lee, S J Kim, Han Hong Lee, J S Kim, J M Park, Y S Cho, K M Lee, S W Kim, Hwang Choi, Myung‐Gyu Choi   +10 more
openalex   +1 more source