Results 131 to 140 of about 249,976 (301)
Advanced Science, EarlyView.We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang +11 more
wiley +1 more source
Optimized scalable Byzantine fault tolerance algorithm
物联网学报, 2020 Blockchain is a decentralized ledger which provides trust to both parties which distrust each other in a transaction.Blockchain initially served as the underlying framework that underpins bitcoin and has increasingly become a disruptive new technology in
Sicheng HAN, Xiaorong ZHU, Xiuxian ZHANG
doaj +2 more sources
Advanced Science, EarlyView.Metastasis remains a major challenge in colorectal cancer. Using an in vivo shRNA screening system, this study identifies Homeobox D4 as a key metastasis suppressor. Reduced Homeobox D4 expression is associated with aggressive tumor features. Functional and mechanistic analyses show that it inhibits epithelial‐mesenchymal transition by repressing ...
Zhi‐hua Ye +9 more
wiley +1 more source
An efficient sharding consensus algorithm for consortium chains. [PDF]
Sci Rep, 2023 Wu X, Jiang W, Song M, Jia Z, Qin J.
europepmc +1 more source
Consensus Acceleration in Multiagent Systems with the Chebyshev Semi-Iterative Method
, 2011 We consider the fundamental problem of reaching consensus in multiagent systems; an operation required in many applications such as, among others, vehicle formation and coordination, shape formation in modular robotics, distributed target tracking, and ...
Jennings, Nick +4 more
core
Advanced Science, EarlyView.This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li +15 more
wiley +1 more source
Fine-tuning structural RNA alignments in the twilight zone
, 2010 Bremges A, Schirmer S, Giegerich R. Fine-tuning structural RNA alignments in the twilight zone. BMC Bioinformatics. 2010;11(1): 222.Background A widely used method to find conserved secondary structure in RNA is to first construct a multiple sequence ...
Bremges Andreas +8 more
core +1 more source
DNA Replication Errors Drive Genome‐Wide Small Inverted Triplication Dynamics
Advanced Science, EarlyView.This study provides insight into the dynamic equilibrium mechanism of a novel structural variant, small inverted triplication (SIT), which is generated by misalignment of the 3’ flap generated under DNA replication stress with palindromic sequence. Alternatively, the end sequence may fold back on itself to form an inverted fragment.
Yi Lei +12 more
wiley +1 more source
Proposed New Blockchain Consensus Algorithm
, 2022 Blockchain technology considers the central technology that is used within many applications used frequently with human life. And the primary core of the blockchain is the consensus algorithm which may affect the security of the chain as well as the ...
Abdul Wahab, Hala B. +1 more
core
Advanced Science, EarlyView.Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi +7 more
wiley +1 more source