Results 61 to 70 of about 491,160 (302)
Research on Convergence Media Ecological Model Based on Blockchain
SystemsCurrently, the media industry is in the rapid development stage of media integration, which has brought about great changes in content production mode, presentation form, communication mechanism, operation and maintenance management, etc.
Hongbin Hu, Yongbin Wang, Guohui Song
doaj +1 more source
Raft consensus mechanism and the applications
Journal of Physics: Conference Series, 2020 Abstract Raft consensus algorithm is one of the commonly used consensus algorithms in distributed systems. It is mainly used to manage the consistency of log replication. It has the same function as Paxos, but compared to Paxos, Raft algorithm is easier to understand and easier to apply to actual systems.
Junjie Hu, Ke Liu
openaire +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Consensus Mechanism in Ethereum 2.0 Blockchain
, 2021 Ethereum platforma za izgradnju pametnih ugovora temelji se na blockchain tehnologiji koja je opisana u radu “Konsenzus u Ethereum 2.0 blockchainu“. PoW konsenzus mehanizam koji se koristi kod platforme Ethereum sprema svako prethodno stanje mreže na
Mustač, David
core
, 2022 The emerging demand for electric vehicles in urban cities leads to the need to install a huge number of charging stations. With this requirement, electric vehicle coordination and scheduling at charging stations in real-time becomes highly tedious. Thus,
Florin-Emilian Turcanu +8 more
core +1 more source
Traceability permissioned chain consensus mechanism based on double-layer architecture
网络与信息安全学报, 2019 The blocks in the blockchain are arranged in chronological and historical order, and the blockchain is incapable of modification through data encryption technology and consensus mechanism, which makes product traceability to be an important application ...
DING Qingyang, ZHU Jianming, XU Yanjing, JIA Chuanchang, GAO Zheng +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Research on Convergence Media Consensus Mechanism Based on Blockchain
, 2022 In recent years, the media industry has achieved rapid development and experienced three development stages from traditional media to new media and then to the current convergence media.
Hongbin Hu, Yongbin Wang
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source