Results 71 to 80 of about 3,887,385 (233)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Research on Convergence Media Ecological Model Based on Blockchain
SystemsCurrently, the media industry is in the rapid development stage of media integration, which has brought about great changes in content production mode, presentation form, communication mechanism, operation and maintenance management, etc.
Hongbin Hu, Yongbin Wang, Guohui Song
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Traceability permissioned chain consensus mechanism based on double-layer architecture
网络与信息安全学报, 2019 The blocks in the blockchain are arranged in chronological and historical order, and the blockchain is incapable of modification through data encryption technology and consensus mechanism, which makes product traceability to be an important application ...
DING Qingyang, ZHU Jianming, XU Yanjing, JIA Chuanchang, GAO Zheng +2 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Research on key technologies of P2P transaction in virtual power plant based on blockchain
IET Smart Grid, 2022 It is a critical part of increasing renewable energy accommodation by using virtual power plant (VPP) to attain carbon neutrality. However, VPP applications primarily consider VPP's participation in power market transactions as a whole and rarely ...
Bin Li +5 more
doaj +1 more source
An Overview and Comparison of Blockchain Consensus Mechanisms [PDF]
International Journal of Networked and Distributed ComputingBlockchain technology has revolutionized digital systems by ensuring trust, transparency, decentralization, and security. However, in the democratic nature of blockchain networks, there is a huge underlying dependency on consensus mechanisms, but the challenges associated with these, such as energy costs, network attacks, preservation of privacy ...
Mutiullah Shaikh +3 more
openaire +3 more sources
Consensus for the Fip35 folding mechanism? [PDF]
The Journal of Chemical Physics, 2013 Recent advances in computational power and simulation programs finally delivered the first examples of reversible folding for small proteins with an all-atom description. But having at hand the atomistic details of the process did not lead to a straightforward interpretation of the mechanism.
Berezovska, Ganna +2 more
openaire +4 more sources
, 2020 THE DIAGNOSIS AND TREATMENT OFPERIPHERAL LYMPHEDEMA: 2020 CONSENSUS DOCUMENTOF THE INTERNATIONAL SOCIETY OF ...
DOCUMENT, CONSENSUS
core
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source