Results 151 to 160 of about 3,413,690 (294)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

HEMOS-Cloud: HPC Cloud-based Modeling and Simulation Platform for HEMOS Software

, 2017
Modeling & Simulation (M&S) is a technology that replaces the physical productionand experimentation of products with virtual production (modeling) and engineeringanalysis (simulation).
김명일, 김재성, 서동우, 정대용   +3 more
core  

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Analysis of Enterprise Modeling Approaches for Modeling Business Strategy

A gap in the alignment of business and IT lies between strategy and IS, despite the advancements of enterprise modeling. The objective of our study is to compare various enterprise modeling approaches with respect to their ability to capture and ...
Giannoulis, Constantinos, Johannesson, Paul, Stirna, Jānis, Zikra, Iyad, Bergholtz, Maria, Zdravkovic, Jelena   +5 more
core  

Cellular diversity in neural organoids is critical for neurodegenerative disease modeling. [PDF]

PLoS Biol
Liu S, Ng SY.
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Modeling the Intellect from a Coordination Perspective

, 2011
Usually, models of the intellect take the individual mind and body as the point of departure and proceed outward towards the social and natural environment in which the individual is immersed. As a consequence, important social dimensions contributing to
Taxén, Lars,
core  

Quantitative Medicine to Support Drug Development and Regulatory Decisions: A UK Regulatory Approach Informed by ICH M15. [PDF]

Clin Transl Sci
Kerwash E, Butler AS, Malamatari M, Cole S.   +3 more
europepmc   +1 more source