Results 61 to 70 of about 1,803,264 (372)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
The internazionalization of research
Conservation Science in Cultural Heritage, 2012 This paper focuses on the importance given to strategies for internationalization and research, two topics currently at the centre of European debate.What is made evident is the concept of investment in terms of knowledge, and human as well as economic ...
Mario Alì
doaj +1 more source
Photon number conservation in time dependent systems [PDF]
arXiv, 2022 Time dependent systems in general do not conserve photons nor do they conserve energy. However when parity time symmetry holds Maxwells equations can sometimes both conserve photon number and energy. Here we show that photon conservation is the more widely applicable law which can hold in circumstances where energy conservation is violated shedding ...
arxiv
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
High Resolution Schemes for Hyperbolic Conservation Laws
, 2017 A class of new explicit second order accurate finite difference schemes for the computation of weak solutions of hyperbolic conservation laws is presented.
A. Harten
semanticscholar +1 more source
FEBS Letters, EarlyView.Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa +8 more
wiley +1 more source
Host-Parasite Co-evolution and Optimal Mutation Rates for Semi-conservative Quasispecies [PDF]
, 2004 In this paper, we extend a model of host-parasite co-evolution to incorporate the semi-conservative nature of DNA replication for both the host and the parasite. We find that the optimal mutation rate for the semi-conservative and conservative hosts converge for realistic genome lengths, thus maintaining the admirable agreement between theory and ...
arxiv +1 more source
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
Ibo Island in the Quirimbas Archipelago. An Architectural Heritage Within a Natural Heritage
Conservation Science in Cultural Heritage, 2019 This paper presents the method adopted in the study of Ibo, a small island of the Quirimbas Archipelago in northern Mozambique. Ibo is part of a larger study, begun in 2004 which is still ongoing. In the first phase, the author's attention was focused on
Maurizio Berti
doaj +1 more source
Population genomics for wildlife conservation and management
Molecular Ecology, 2020 Biodiversity is under threat worldwide. Over the past decade, the field of population genomics has developed across nonmodel organisms, and the results of this research have begun to be applied in conservation and management of wildlife species. Genomics
Paul A Hohenlohe, W. Funk, O. Rajora
semanticscholar +1 more source