Results 61 to 70 of about 699,751 (248)

The individuation of Cultural Heritage owned by the State and by non profit private bodies

open access: yesConservation Science in Cultural Heritage, 2004
The individuation of the cultural heritage is the first step to be carried out before subjecting the cultural heritage to the legal preservation regime.
Nicola Aicardi
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Microclimate Management for the Preservation of Cultural Heritage

open access: yesConservation Science in Cultural Heritage, 2010
This paper presents a line of research aimed at studying in detail the interaction between air conditioning/heating systems and thermo hygrometric conditions inside museums.
Salvatore Alterio   +4 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Art and environment as media for ecosustainability, ethics and aesthetics

open access: yesConservation Science in Cultural Heritage, 2012
“Art, both in a strict sense, but also in a broader sense, that is to say environmental and cultural heritage – considering, as it correctly should be, the environment with its individual compartments of air, soil and water – is indissolubly linked to ...
Salvatore Lorusso, Angela Braida
doaj   +1 more source

Conservative Progress [PDF]

open access: yesThe Boston Medical and Surgical Journal, 1884
The advance of science is hindered not more by obstinacy than by fickleness. The skepticism which uses an honest crucible is a blessing; the skepticism which wields a club, and smashes old things indiscriminately because they are ancient, is a curse. Underneath its destructive malice is often a credulous and craven tenderness for anything which is new.
openaire   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

A note from the restoration world: the Raffaello completed?

open access: yesConservation Science in Cultural Heritage, 2002
History of a restoration work that had opened the way to a new, fascinating attribution hypothesis for a drawing that was considered a Giulio Romano’s work and today it is considered a Raffaello’s work, with a subsequently partial intervention of his ...
Pietro Livi
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

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