Results 131 to 140 of about 342,303 (293)

Editorial: The Wildlife Gut Microbiome and Its Implication for Conservation Biology. [PDF]

Front Microbiol, 2021
Zhu L, Wang J, Bahrndorff S.
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Chromosome-Level Genome Assemblies Expand Capabilities of Genomics for Conservation Biology. [PDF]

Genes (Basel), 2021
Totikov A, Tomarovsky A, Prokopov D, Yakupova A, Bulyonkova T, Derezanin L, Rasskazov D, Wolfsberger WW, Koepfli KP, Oleksyk TK, Kliver S.   +10 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

COVID-19 and the opportunities for research: The lockdowns' impacts on wildlife, ecology and conservation biology, and the humanities. [PDF]

EMBO Rep, 2021
Hunter P.
europepmc   +1 more source

Conservation limits and management opportunities for fall migrants along the lower Delmarva Peninsula

, 2013
The lower Delmarva Peninsula is one of the most significant migration bottlenecks in eastern North America where large numbers of birds become concentrated within a relatively small land area.
Wilson, M. D., Watts, B. D.
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Defining 'Biodiversity'; Assessing Biodiversity [PDF]

, 2001
This paper analyzes the concept of biodiversity in conservation biology and assesses potential methods for its ...
Sarkar, Sahotra
core  

Conservation and the 4 Rs, which are rescue, rehabilitation, release, and research

, 2018
© 2017 Society for Conservation Biology Vertebrate animals can be injured or threatened with injury through human activities, thus warranting their “rescue.” Details of wildlife rescue, rehabilitation, release, and associated research (our 4 Rs) are ...
Pyke, GH, Graham H. Pyke, Judit K. Szabo, Szabo, JK   +3 more
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source