Results 181 to 190 of about 342,303 (293)

Enhancing disciplinary diversity and inclusion in conservation science and practice based on a case study of the Society for Conservation Biology. [PDF]

Conserv Biol
Winkler-Schor S, Eyster HN, Lobo D, Redmore L, Wright AJ, Lukasik VM, Chávez-Páez W, Tully B, Beard S, Blount-Hill KL, Christen C, Nyssa Z.   +11 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Toward telomere-to-telomere cat genomes for precision medicine and conservation biology. [PDF]

Genome Res
Murphy WJ, Harris AJ.
europepmc   +1 more source

Relationship between conservation biology and ecology shown through machine reading of 32,000 articles. [PDF]

Conserv Biol, 2020
Hintzen RE, Papadopoulou M, Mounce R, Banks-Leite C, Holt RD, Mills M, T Knight A, Leroi AM, Rosindell J.   +8 more
europepmc   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Introduction to the Special Issue of Plants on "Advances in Plant Reproductive Ecology and Conservation Biology". [PDF]

Plants (Basel)
Molano-Flores B, Cohen JI.
europepmc   +1 more source

Assessing the impact of planned linear infrastructure on ecological connectivity: an example from Uganda and South Sudan

In an increasingly interconnected world, where human activities and infrastructure development continue to reshape landscapes, environmental fragmentation is one of the main threats to biodiversity and ecosystems.
Bacaro G., Fonda F, Bullegas F
core  

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Integrating bioenergetics and conservation biology: thermal sensitivity of digestive performance in Eastern Collared Lizards (Crotaphytus collaris) may affect population persistence. [PDF]

Conserv Physiol, 2020
Brewster CL, Ortega J, Beaupre SJ.
europepmc   +1 more source