Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Spatial genetic structure in the saddled sea bream (Oblada melanura [Linnaeus, 1758]) suggests multi-scaled patterns of connectivity between protected and unprotected areas in the Western Mediterranean Sea [PDF]
, 2016 Marine protected areas (MPAs) and networks of MPAs are advocated worldwide for the achievement of marine conservation objectives. Although the knowledge about population connectivity is considered fundamental for the optimal design of MPAs and networks ...
Calo A. +4 more
core +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Microsatellite loci development and population genetics in Neotropical fish Curimata mivartii (Characiformes: Curimatidae) [PDF]
PeerJ, 2018 The Curimatidae family plays an ecological role in the recycling and distribution of nutrients and constitutes a major food source for several commercially important fishes.
Ricardo M. Landínez-García +1 more
doaj +2 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Genética de poblaciones amazónicas: la historia evolutiva del jaguar, ocelote, delfín rosado, mono lanudo y piurí, reconstruida a partir de sus genes [PDF]
Animal Biodiversity and Conservation, 2007 Amazon population genetics: the evolutionary history of the jaguar, ocelot, pink river dolphin, woolly monkey and wattled curassow reconstructed through their genes The Amazon has more than the half of the world’s biodiversity. Nevertheless, the major
Ruiz-García, M. +4 more
doaj
Diet Analysis for Wildlife Management: Protecting the Cheetah in Namibia [PDF]
, 2015 I spent the summer of 2014 in the genetics laboratory of the Cheetah Conservation Fund (CCF) in Namibia, Africa, to learn about the diets of the carnivores in the surrounding conservancy.
Walsh, Alicia
core +2 more sources
Population Genetics of Rare Variants and Complex Diseases [PDF]
, 2012 Identifying drivers of complex traits from the noisy signals of genetic variation obtained from high throughput genome sequencing technologies is a central challenge faced by human geneticists today.
Hernandez, Ryan D. +3 more
core +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source