Results 61 to 70 of about 145,138 (286)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Population structure and genetic diversity of trout (Oncorhynchus mykiss) above and below natural and man-made barriers in the Russian River, California

, 2007
The final publication is available at link.springer.com. Link to abstract: http://link.springer.com/article/10.1007/s10592-006-9183-0The effects of landscape features on gene\ud flow in threatened and endangered species play an\ud important role in ...
Deiner, Kristy, Garza, John Carlos, Coey, Robert, Girman, Derek J.   +3 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Population genetics for animal conservation

, 2009
It is widely accepted among conservation biologists that genetics is, more than ever, an essential and efficient tool for wild and captive population management and reserve design.
Bruford, Michael William, Hauffe, H.C., Bruford, M.W., Bertorelle, G., Vernesi, C., Rizzoli, A., Hauffe, H. C.   +6 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Conservation genetics of an island toad: Bufo bufo in Jersey [PDF]

, 2007
On Jersey (British Channel Islands), common toads often reproduce in small, urban ponds. This atypical breeding strategy has implications for their persistence and they have declined on the island in recent times.
John W Wilkinson (16063541), Beebee, Trevor J.C., Wilkinson, John W., Richard A Griffiths (16063544), Trevor J C Beebee (16060847), Griffiths, Richard A.   +5 more
core  

Genética de poblaciones amazónicas: la historia evolutiva del jaguar, ocelote, delfín rosado, mono lanudo y piurí, reconstruida a partir de sus genes [PDF]

Animal Biodiversity and Conservation, 2007
Amazon population genetics: the evolutionary history of the jaguar, ocelot, pink river dolphin, woolly monkey and wattled curassow reconstructed through their genes The Amazon has more than the half of the world’s biodiversity. Nevertheless, the major
Ruiz-García, M., Murillo, A., Corrales, C., Romero-Aleán, N., Álvarez-Prada, D.   +4 more
doaj  

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

In situ conservation and landscape genetics in forest species

, 2011
Conservation of forest genetic resources is essential for sustaining the environmental and productive values of forests. One of the environmental values is the conservation of the diversity that is assessed through the amount of genetic diversity stored ...
M.A. Herrera, M.A. Martín, Martín L.M., Herrera, M.A., Martín, M.A., Martín , L.M., Herrera M.A, Martín M.A, L.M. Martín   +8 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source