Results 41 to 50 of about 131,240 (249)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Genética de poblaciones amazónicas: la historia evolutiva del jaguar, ocelote, delfín rosado, mono lanudo y piurí, reconstruida a partir de sus genes [PDF]
Animal Biodiversity and Conservation, 2007 Amazon population genetics: the evolutionary history of the jaguar, ocelot, pink river dolphin, woolly monkey and wattled curassow reconstructed through their genes The Amazon has more than the half of the world’s biodiversity. Nevertheless, the major
Ruiz-García, M. +4 more
doaj
Conservation Genetics, Precision Conservation, and De‐extinction [PDF]
Hastings Center Report, 2017 AbstractIt has been estimated that three species on the planet now go extinct every hour and that this rate is orders of magnitude higher than the planet has seen in previous catastrophic extinction events. We clearly are in the midst of a sixth extinction, and this one is different from the previous five. Why?
Rob, Desalle, George, Amato
openaire +2 more sources
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Scientific Reports, 2023 Research on habitat preferences is an important part of contemporary ecology. For the European bison, the classic approach to distinguishing habitat features is still being followed, but the limitations of this approach cannot provide the standard ...
Daniel Klich +5 more
doaj +1 more source
Genetic variation in subdivided populations and conservation genetics [PDF]
Heredity, 1986 The genetic differentiation of populations is usually studied by using the equilibrium theory of Wright's infinite island model. In practice, however, populations are not always in equilibrium, and the number of subpopulations is often very small.
S L, Varvio, R, Chakraborty, M, Nei
openaire +2 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Genetic diversity and conservation in Bromeliaceae based on SSR markers [PDF]
Genetics and Molecular BiologyBromeliaceae has been used as a model Neotropical group to study evolutionary and diversification processes. Moreover, since large parts of the Neotropics are under anthropogenic pressure, a high percentage of possibly threatened species occurs.
Milene Ferreira Barcellos +2 more
doaj +1 more source