Results 51 to 60 of about 1,774,466 (281)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Importance of Genetics in the Interpretation of Favourable Conservation Status

, 2009
“Favourable Conservation Status” (FCS) is a central concept in the biodiversity conservation legislation of the European Union (EU). Here, we highlight the importance of incorporating aspects of conservation genetics in interpretation of this concept ...
LINDA LAIKRE, Nilsson, T,, Primmer, CR,, TORBJÃRN NILSSON, Laikre, Linda,, CRAIG R. PRIMMER, FRED W. ALLENDORF, Ryman, Nils,, Allendorf, FW,, NILS RYMAN   +9 more
core   +1 more source

Genética de poblaciones amazónicas: la historia evolutiva del jaguar, ocelote, delfín rosado, mono lanudo y piurí, reconstruida a partir de sus genes [PDF]

Animal Biodiversity and Conservation, 2007
Amazon population genetics: the evolutionary history of the jaguar, ocelot, pink river dolphin, woolly monkey and wattled curassow reconstructed through their genes The Amazon has more than the half of the world’s biodiversity. Nevertheless, the major
Ruiz-García, M., Murillo, A., Corrales, C., Romero-Aleán, N., Álvarez-Prada, D.   +4 more
doaj  

Conservation Genetics, Precision Conservation, and De‐extinction [PDF]

Hastings Center Report, 2017
AbstractIt has been estimated that three species on the planet now go extinct every hour and that this rate is orders of magnitude higher than the planet has seen in previous catastrophic extinction events. We clearly are in the midst of a sixth extinction, and this one is different from the previous five. Why?
Rob, Desalle, George, Amato
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The value of avian genomics to the conservation of wildlife [PDF]

, 2009
Background: Genomic studies in non-domestic avian models, such as the California condor and white-throated sparrow, can lead to more comprehensive conservation plans and provide clues for understanding mechanisms affecting genetic variation, adaptation ...
Hickenbotham, Matthew T, Mardis, Elaine R., Dandekar, Sugandha, Modi, William S, Modi, William S., Jones, Kenneth C., Papp, Jeanette C, Mardis, Elaine R, Glasscock, Jarret, Houck, Marlys L, Green, Eric D, Chemnick, Leona G., Otten, Christie A, Stremel Mork, Emily M., Green, Eric D., Chemnick, Leona G, Stremel Mork, Emily M, Papp, Jeanette C., Romanov, Michael N, Magrini, Vincent, Ryder, Oliver A, Hickenbotham, Matthew T., NISC Comparative Sequencing Program,, Otten, Christie A., Tuttle, Elaina M., Tuttle, Elaina M, Houck, Marlys L., Korody, Marisa L, Renner, Tanya, Jones, Kenneth C, Da, Yang, McGrath, Sean, Korody, Marisa L., Ryder, Oliver A.   +33 more
core   +3 more sources

An assessment of the habitat preferences of European bison with airborne laser scanning data in forest ecosystem

Scientific Reports, 2023
Research on habitat preferences is an important part of contemporary ecology. For the European bison, the classic approach to distinguishing habitat features is still being followed, but the limitations of this approach cannot provide the standard ...
Daniel Klich, Krzysztof Stereńczak, Maciej Lisiewicz, Maria Sobczuk, Angelika Nieszała, Wanda Olech   +5 more
doaj   +1 more source

Genetic variation in subdivided populations and conservation genetics [PDF]

Heredity, 1986
The genetic differentiation of populations is usually studied by using the equilibrium theory of Wright's infinite island model. In practice, however, populations are not always in equilibrium, and the number of subpopulations is often very small.
S L, Varvio, R, Chakraborty, M, Nei
openaire   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source