Results 61 to 70 of about 374,356 (270)

Population Genetics of Franciscana Dolphins (Pontoporia blainvillei): Introducing a New Population from the Southern Edge of Their Distribution [PDF]

, 2015
Due to anthropogenic factors, the franciscana dolphin, Pontoporia blainvillei, is the most threatened small cetacean on the Atlantic coast of South America.
A Dornburg, AB Sellas, AE Dizon, AJ Drummond, Alfredo Daniel Vitullo, APM Di Beneditto, AR Hoelzel, AR Hoelzel, AR Hoelzel, AR Rogers, AR Rogers, AR Rogers, Cristina Beatriz Dejean, Crowe GM O’Corry, D Charlesworth, D Posada, D Posada, E Valsecchi, EA Crespo, EA Crespo, EA Crespo, ER Secchi, ER Secchi, ER Secchi, ER Secchi, ER Secchi, F Rousset, F Tajima, GP Donovan, H Hamilton, HA Cunha, HA Lessios, HC Harpending, HJ Bandelt, HL Cappozzo, Humberto Luis Cappozzo, IC Ansmann, J Sambrook, JL Bossart, JL Jensen, JR Franklin, Juan Ignacio Túnez, KJ Fullard, KM Parsons, L Chen, L Excoffier, L Xu, LD Adams, M Failla, M Lázaro, M Mendez, M Mendez, MA Larkin, María Constanza Gariboldi, María Fernanda Negri, Mauricio Failla, MF Negri, N Ray, NJ Ouborg, P Berggren, P Bordino, P Bordino, P Librado, P Mardulyn, PE Rosel, PG Meirmans, R Frankham, R Nielsen, RS Waples, RS Wells, S Caballero, S Schneider, Sergios-Orestis Kolokotronis, SYW Ho, SYW Ho, SYW Ho, TD Kocher, TD Kocher, TL King, Urrutia P Costa, WS Grant, YX Fu   +81 more
core   +3 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Protein structure and phenotypic analysis of pathogenic and population missense variants in STXBP1 [PDF]

, 2017
Background: Syntaxin-binding protein 1, encoded by STXBP1, is highly expressed in the brain and involved in fusing synaptic vesicles with the plasma membrane.
Baker, K, Clayton-Smith, J, Dabir, T, DDD Study, Evers, JMG, Josifova, D, Joss, S, Kerr, B, Kraus, A, Laskowski, RA, McEntagart, M, Morton, J, O'Brien, S, Smith, A, Splitt, M, Suri, M, Thornton, JM, Wright, CF   +17 more
core   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Population genetics for insect conservation and control

Conservation Science and Practice
Insects are essential not only for ecosystem functioning and food security but also comprise some of the world's most destructive invasive species. Therefore, both insect declines and invasions raise major conservation concerns globally and call for ...
Alexis L. Beaurepaire, Matthew T. Webster, Peter Neumann   +2 more
doaj   +1 more source

Reliable wolf-dog hybrid detection in Europe using a reduced SNP panel developed for non-invasively collected samples

BMC Genomics, 2021
Background Understanding the processes that lead to hybridization of wolves and dogs is of scientific and management importance, particularly over large geographical scales, as wolves can disperse great distances.
Jenni Harmoinen, Alina von Thaden, Jouni Aspi, Laura Kvist, Berardino Cocchiararo, Anne Jarausch, Andrea Gazzola, Teodora Sin, Hannes Lohi, Marjo K. Hytönen, Ilpo Kojola, Astrid Vik Stronen, Romolo Caniglia, Federica Mattucci, Marco Galaverni, Raquel Godinho, Aritz Ruiz-González, Ettore Randi, Violeta Muñoz-Fuentes, Carsten Nowak   +19 more
doaj   +1 more source

Genetic Selection and Conservation of Genetic Diversity* [PDF]

Reproduction in Domestic Animals, 2012
ContentsFor 100s of years, livestock producers have employed various types of selection to alter livestock populations. Current selection strategies are little different, except our technologies for selection have become more powerful. Genetic resources at the breed level have been in and out of favour over time.
openaire   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

No evidence for a recent genetic bottleneck in the endangered Sheko cattle breed (African Bos taurus) revealed by microsatellite analysis [PDF]

, 2009
Sheko is African taurine cattle, valued for its milk yield, adaptation to humid tsetse infested environment and trypanotolerance. We used 30 microsatellite markers in analyzing 30 DNA samples. We found high genetic diversity and no genetic bottlenecks in
Hailu Dadi, Hirofumi Hanada, Joram Mwacharo, Koh Nomura, Markos Tibbo, Takashi Amano, Yukimizu Takahashi   +6 more
core   +1 more source